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French Alliance for Parasitology and Health Care

[Communiqué]

Gerald Spaeth, head of the "Molecular Parasitology and Signalling" unit at the Institut Pasteur Paris, has been awarded a Synergy grant from the European Research Council (ERC) for the project "DECOLeishRN - Decoding epistatic genome/RNome interactions in ekaryotic fitness gain using Leishmania parasites as a unique model system". This project is funded at over 9 millions Euros and will be conducted in collaboration with two Israeli teams led by Shulamit Michaeli (Bar-Ilan University) and Yitzhak Pilpel (Weizmann Institute of Science).

ERC logo

Exploiting the unique biology of the protozoan parasite Leishmania as a model system, the project will generate unprecedented insight into the role of genome instability in eukaryotic adaptation by combining experimental evolution, analyses of the non-coding RNA, network modelling and cutting-edge, single cell sequencing. The project aims to uncover the molecular filter that can mitigate toxic effects of genome instability while promoting beneficial ones, thus resolving a long-standing question in infection and cancer biology.

The six-year project (2023-2029) is poised to reveal complex and dynamic interactions between genomic, epitranscriptomic and phenotypic adaptation of these important parasites, and the role of stress-adapted ribosomes and non-coding RNAs – especially anti-sense regulators – that compensate for detrimental gene dosage changes. The scientists will further examine whether the parasite has the capacity to predict and prepare in advance to changes in environmental conditions and the switch between its hosts. The study of pathogen evolution within a mammalian host will provide an innovative framework for the discovery of complex biomarker candidates linked to Leishmania virulence and drug resistance. Exploiting genome instability for adaptation is common to other diseases-causing microbes and cancer. This ERC Synergy grant will thus deliver a blueprint to study how chaotic genome instability is harnessed for adaptation and to escape unfavorable environmental conditions.

[Communiqué]

The team of Dr Chetan Chitnis from the Institut Pasteur, a partner in LabEx ParaFrap, has studied the blood stage of the Plasmodium falciparum parasite, which causes the most severe and deadly form of malaria, and discovered a mechanism that could lead to the development of new effective drugs against malaria. The results of this study were published in a communication of Institut Pasteur.

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Work published in Cell Reports : Matthias Paulus Wagner, Pauline Formaglio, Olivier Gorgette, Jerzy Michal Dziekan, Christèle Huon, Isabell Berneburg, Stefan Rahlfs, Jean-Christophe Barale, Sheldon I. Feinstein, Aron B. Fisher, Didier Ménard, Zbynek Bozdech, Rogerio Amino, Lhousseine Touqui, Chetan E. Chitnis (2022) Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target. Cell Reports, Volume 39, Issue 11. doi: 10.1016/j.celrep.2022.110923.

 

 

Dear colleagues,

The EMBO Workshop "New frontiers in host-parasite interactions, from cell to organism", supported by ParaFrap,  is now open for registration. The deadlines for online abstract submission and registration are July 13th 2022. Please register here: 

Registration

This workshop will be held from 2-5 October 2022, at the "Île des Embiez", a French island in the Mediterranean Sea (https://www.lesilespaulricard.com/?lang=en).

Parasitic infections remain a major cause of morbidity and mortality worldwide; they kill millions annually and inflict debilitating injuries on additional millions. The vast majority of parasitic infections in humans and domestic animals can be attributed to protozoan pathogens, including those causing malaria, African sleeping sickness, leishmaniasis, or toxoplasmosis. Parasitism is found throughout the tree of life and parasitic organisms have become model systems for the study of biochemistry and molecular biology. They also represent valuable systems for integrated analyses of host-pathogen interplay.

The workshop will showcase the latest breakthroughs in host-parasite interactions at the cell, tissue and organism levels, including sessions on host manipulation and avoidance strategies, host immune responses  and pathogenesis, parasite cell biology, parasite molecular biology and signaling, parasite reservoirs and niches, vaccination and control strategies. The conference will cover multiple protozoan parasites  (Plasmodium, Toxoplasma, Cryptosporidium, Trypanosoma, Leishmania) and provide an outstanding opportunity to share cutting-edge science. We aim to promote interactions and discussions, especially with junior scientists. The meeting will include poster sessions and turbo talks, providing younger researchers the opportunity to present their work. It will represent a stimulating environment to exchange ideas and envisage novel approaches to deal with pathogenic parasites.

We are looking forward to meeting you at this workshop and hearing about your exciting science.

Olivier SILVIE and Nicolas BLANCHARD
Scientific organizers

Yoann MILLERIOUX
ParaFrap manager

Artur SCHERF, Mohamed-Ali HAKIMI, Frederic BRINGAUD, Maria MOTA, Dominique SOLDATI-FAVRE, Elena LEVASHINA
Co-Organizers

CONFIRMED SPEAKERS
Yasmine Belkaid, NIH, Bethesda, USA
John Boothroyd, Stanford University School of Medicine, Stanford, USA
Michael Boshart, Ludwig-Maximilians-University, Munich, Germany
Hernando Del Portillo, Institut de Salut Global, Barcelona, Spain
Abdoulaye Djimde, Malaria Research and Training Center, Bankoumana, Mali
Luisa Figueiredo, Institute for Molecular Medicine, Lisbon, Portugal
Eva Frickel, University of Birmingham, UK
Freddy Frischknecht, Heidelberg University, Heidelberg, Germany
Mohamed-Ali Hakimi, Institute for Advanced Biosciences, Grenoble, France
Benoit Gamain, French National Institute of Blood Transfusion, Paris, France
Paul Kaye, University of York, UK
Taco Kooij, EMBO Young Investigator, Radboud University, Nijmegen, Netherlands
Maryse Lebrun, University of Montpellier, France
Elena Levashina, Max Planck Institute for Infection Biology, Berlin, Germany
Keith Matthews, University of Edinburgh, UK
Annette McLeod, University of Glasgow, UK
Maria Mota, Institute for Molecular Medicine, Lisbon, Portugal
Faith Osier, Imperial College London, UK
Silvia Portugal, Max Planck Institute for Infection Biology, Berlin, Germany
Isabel Roditi, University of Bern, Switzerland
David Sacks, NIH, Bethesda, USA
Dominique Soldati-Favre, University of Geneva, Switzerland
Boris Striepen, University of Pennsylvania, Philadelphia, USA
Rick L. Tarleton, University of Georgia, Athens, USA
Hedda Wardemann, German Cancer Research Center, Heidelberg, Germany
Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands

 

LabEx ParaFrap wishes you a happy, healthy and successful year 2022. We already have 2 exciting news to start this year:

- ParaFrap webinars will continue in 2022, will be open to all and you will soon be able to register to attend them (beginning of February)

- The Embo Workshop "New frontiers in host-parasite interactions, from cell to organism" will be held from October 2 to 5, 2022, on the Ile des Embiez. You can enter your email address on https://coming-soon.embo.org/w22-33 to be informed when the website is online and registration is open.

Voeux2022

 

From 27 to 29 September 2021, the LabEx ParaFrap organised a PI meeting on Les Embiez Island (Var, France). The aim of this meeting was to promote exchanges and discussions between partners.

BastienP retirement 

It was also an opportunity to celebrate the retirement of Patrick Bastien, who was previously the coordinator of the PhD programme. Yvon Sterkers is taking over this function and Patrick becomes the Advisor of the PhD programme.

In addition, Maryse Lebrun joined the LabEx ParaFrap steering committee as Scientific Coordinator.

PIMeeting2021

 

 

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TRAINING PROGRAM

International PhD Program

NEWS

LabEx News
Other News

 

CONTACT

Project Manager: Yoann MILLERIOUX
Contact

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