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French Parasitology Alliance For Health Care


 

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Please note : The date at which shortlisted candidates will be invited for the final interview process has been postponed to the 10th May. These final interviews will take place online on the 21-22-23rd June 2021. 

The international PhD program of the French national research project 'ParaFrap' is currently open for applications for 17 Ph.D. positions to be started in October 2021.

PRESENTATION

The LabEx (Laboratory of Excellence) ParaFrap is a Health Sciences collaborative research program focusing on Molecular and Cellular Parasitology in its wider sense. The network gathers 26 French leading groups in the field and is funded by the Excellence Initiative of the French Ministry of Research. Four major research fields are investigated in protozoan models such as PlasmodiumToxoplasmaLeishmaniaTrypanosoma and Cryptosporidium:

Ø  Post-genomic data exploration
Ø  Mechanisms of pathogenesis and protective immunity
Ø  Parasite molecular and cellular biology
Ø  Towards new intervention strategies against parasitic pathogens

The ParaFrap International Ph.D. program is an ambitious program offering competitive Ph.D. grants to high-quality students/early stage scientists. Applications are open to non-French students. The early stage scientists will be joining research projects selected by an external scientific board and managed by a main supervisor and a co-supervisor from two distinct research groups of the LabEx. These core research projects will focus on the use of state-of-the-art post-genomic tools to enhance knowledge of the parasites' biology and of their interactions with their hosts. We are committed to providing ParaFrap Ph.D. students with the best starting platform for a successful career in science. Additional information about ParaFrap can be found on http://www.labex-parafrap.fr/en/.

APPLICATION

Eligibility requirements

1. Applicants must have achieved academic excellence and be highly motivated to pursue a Ph.D. project in Parasitology. They should have obtained a 'Masters 2' degree or an equivalent (5 years after high/secondary school) in science by July 2021; out of this format, only exceptional applications (upon justification) will be considered by the program director.

2. English language skills are mandatory.

3. The PhD program does not have an age restriction, but most accepted candidates are 24-26 years old and start their Ph.D. within a year of finishing their M.Sc., a few of them within 3 years.

4. Mobility between the Master's lab and the Ph.D. host lab is mandatory, meaning that the applicants must change from their present Research Director and Institute to another for the Ph. D. training.

Deadline

The deadline for submitting an application is on the 10th April 2021.

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PhD research projects

 TITLE Main PI

How does T. gondii modulate neuronal responses and antigen presentation to evade immune recognition throughout chronic infection?

Nicolas BLANCHARD

Characterization of a central transcriptional regulator for the metabolic adaptation of Toxoplasma towards its host

Cyrille BOTTÉ

Role(s) of glycerol metabolism in the biology of African trypanosomes

Frédéric BRINGAUD

Role of a host peroxiredoxin in blood stage growth of malaria parasites

Chetan E. CHITNIS

How do parasites manipulate the behaviour of their vectors? A comparative spatial transcriptomic study in Anopheles and Glossina sensory organs.

Anna COHUET

Optimisation of antiparasitic redox-active 3-benzylmenadiones and of drug partners for effective drug combination by oral administration

Elisabeth

DAVIOUD-CHARVET

Study of in vivo P. vivax and falciparum – host bone marrow interactions

Sylvie GARCIA

The molecular drivers of antigenic variation in African Trypanosomes

Lucy GLOVER

The Epigenetic Role(s) of MORC-containing Complexes Operating in the Hidden Face of the T. gondii Life Cycle or Regulating Virulence Genes in the Human Malaria Parasite

Mohamed-Ali HAKIMI

PfPP1 contribution to egress in asexual and sexual stages of the malaria parasite Plasmodium falciparum

Mauld H. LAMARQUE

Identification of curative treatments to control cryptosporidiosis and the associated molecular mechanism

Fabrice LAURENT

Deciphering how erythroblast infection by Plasmodium falciparum induces a delay in erythropoiesis

Catherine LAVAZEC

Studying two complementary infection models to identify common mechanisms of intracellular parasite survival: The roles of Leishmania and Eimeria exo-kinases in subversion of host cell signalling.

Najma RACHIDI

DevDermTryp – Development of dermal trypanosomes

Brice ROTUREAU

Targeting a Plasmodium propeller domain protein to prevent malaria liver stage infection

Olivier SILVIE

Unravelling the role of epigenetic factors which control the DNA replication in Leishmania

Yvon STERKERS

How does a Toxoplasma gondii bradyzoite cope with the small intestine surface biochemical, topographical and rheological properties to colonize the enterocytes

Isabelle TARDIEUX

 

Information about the PhD research projects, selection process, as well as the application procedure, is available at  https://parafrap.application.systemsAll applications MUST be made online on this website.

Successful applicants will be enrolled in one of the 17 research groups who were awarded a Ph.D. fellowship, distributed among diverse French Universities (see website). Each applicant will have to indicate 4 projects of interest. If selected, he/she should be enrolled in one of the four projects indicated, unless the selection committee sees a particular interest in modifying one of his/her options.

SELECTION PROCEDURE

       Pre-selectionApplicants will be selected by a committee formed by group leaders of each of the participating laboratories, based on the high standards used at EMBL, including academic achievements, previous experience in research, and (blind) letters of recommendation. Each PI will rank five applicants according to his/her CV, academic records, laboratory experience and letters of recommendation from referees.

       Interviews: The ParaFrap selection committee will then invite a shortlist of 35-40 candidates for the final selection round, i.e. interviews in front of the whole panel of PIs of the programme. These interviews will take place between June 15th and June 23rd at Institut Pasteur in Paris or remotely by video, depending on the pandemic situation. If on site, travel and accommodation expenses will be covered by ParaFrap.

       Final selection: After ranking by the selection committee, letters of acceptance will be sent immediately to the top 17 candidates, who will be asked to give their approval in the following week. The remaining candidates will be informed of their ranking. Should a candidate refuse the offer, the first candidate in the waiting list will receive a letter of acceptance.

SUPERVISION OF THE PhD THESIS WORK

The PhD. student will be supervised by his/her thesis supervisor and the main collaborator (‘co-PI’) in the projectwho has to be from another institute. A Ph.D. thesis committee will interview the student at the end of the 1st and 2nd year and produce a mid-report to the Doctoral School of the University.

THESIS CONTRACT 

       Duration: The selected Ph.D. students will be recruited on a fixed-term contract of 36 months.

    Studentship: The maximum gross monthly salary will be 2500 €, depending on the Research Institutions. The Ph.D. students will receive private health insurance and social security entitlements.

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PhD Program provisional planning

April 10th, 2021 Application deadline
April  15th, 2021 Referees deadline (blind letters of recommendation)
May 10th 2021 Invitations for interviews sent to applicants
June 21st-23rd, 2021 Interviews  and notification of the results
June 30th, 2021 Definitive acceptance by the selected applicants
September 1st, 2021 Start of the Ph.D.

 

 

 

Given the current Covid-19 situation, the EMBO Workshop “New frontiers in host-parasite interactions, from cell to organism”, initially planned in October 2020, is rescheduled to 03-06 October 2021, at the same venue, Les Embiez Island, South of France.

More details coming soon.

Follow this link and enter your e-mail address to be notified when the website is launched, and follow our Twitter account @ParaFrap for updates.

We aim to promote interactions and discussions, especially with junior scientists. The meeting will include poster sessions and turbo talks, providing younger researchers the opportunity to present their work. It will represent a stimulating environment to exchange ideas and envisage novel approaches to deal with pathogenic parasites.

The workshop will showcase the latest breakthroughs in host-parasite interactions at the cell, tissue and organism levels, including sessions on host manipulation and avoidance strategies, host immune responses and pathogenesis, parasite cell biology, parasite molecular biology and signaling, parasite reservoirs and niches, vaccination and control strategies. The conference will cover multiple protozoan parasites (Plasmodium, Toxoplasma, Cryptosporidium, Trypanosoma, Leishmania) and provide an outstanding opportunity to share cutting-edge science. 

EMBO2021

In the article Nuevos medicamentos para combatir la enfermedad de Chagas (New drugs to fight Chagas disease) published in the review Nuestra Ciencia* N. 22 of October 2020, the authors present the treatments currently used to treat Chagas disease and, in particular, discuss current research on drugs to fight this disease.

One of the authors of this article is Andrea Vela, doctoral student of the ParaFrap PhD South programme under the supervision of Dr Frédérique Brennière (IRD UMR Intertryp / ParaFrap). Her thesis project, funded by ParaFrap, aims to evaluate the action of molecules developed in the chemistry department at the University of Strasbourg (France), on genetic variants of Trypanosoma cruzi found in Ecuador.

Find this article (in Spanish) pages 3-6 of the review.

*Nuestra Ciencia is an annual review proposed by the Pontifical Catholic University of Ecuador (Pontificia Universidad Católica del Ecuador).

NuestraCiencia22 Cover

 

With more than 500 followers, the @ParaFrap Twitter account allows a worldwide sharing of information about our LabEx and from the parasitology community: scientific discoveries, meetings, job offers... The international visibility of France as a leader in parasitology is thus strengthened, which has been one of the main objectives of the LabEx ParaFrap since its launch in 2012.

#ThankYou

Twitter 500 ParaFrap

 

Today, Tuesday, April 28 2020, Dr Cyrille Botte and the ApicoLipid team, ParaFrap partner, is running the #LipidTakeover on the Journal of Lipid Research @jlipidres Twitter account. Join them as they discuss membrane biogenesis, metabolism of infectious parasitic diseases and more! (US EST Time 9am-5pm / CEST 3pm-11pm)

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