Gerald Spaeth, head of the "Molecular Parasitology and Signalling" unit at the Institut Pasteur Paris, has been awarded a Synergy grant from the European Research Council (ERC) for the project "DECOLeishRN - Decoding epistatic genome/RNome interactions in ekaryotic fitness gain using Leishmania parasites as a unique model system". This project is funded at over 9 millions Euros and will be conducted in collaboration with two Israeli teams led by Shulamit Michaeli (Bar-Ilan University) and Yitzhak Pilpel (Weizmann Institute of Science).
Exploiting the unique biology of the protozoan parasite Leishmania as a model system, the project will generate unprecedented insight into the role of genome instability in eukaryotic adaptation by combining experimental evolution, analyses of the non-coding RNA, network modelling and cutting-edge, single cell sequencing. The project aims to uncover the molecular filter that can mitigate toxic effects of genome instability while promoting beneficial ones, thus resolving a long-standing question in infection and cancer biology.
The six-year project (2023-2029) is poised to reveal complex and dynamic interactions between genomic, epitranscriptomic and phenotypic adaptation of these important parasites, and the role of stress-adapted ribosomes and non-coding RNAs – especially anti-sense regulators – that compensate for detrimental gene dosage changes. The scientists will further examine whether the parasite has the capacity to predict and prepare in advance to changes in environmental conditions and the switch between its hosts. The study of pathogen evolution within a mammalian host will provide an innovative framework for the discovery of complex biomarker candidates linked to Leishmania virulence and drug resistance. Exploiting genome instability for adaptation is common to other diseases-causing microbes and cancer. This ERC Synergy grant will thus deliver a blueprint to study how chaotic genome instability is harnessed for adaptation and to escape unfavorable environmental conditions.
Postdoctoral position, Institut Pasteur, Paris, France A postdoc position is available at the Institut Pasteur Paris, in the signalling and host-parasite interactions research group, headed by Dr Najma Rachidi...
Postdoctoral Research Associate, York, UK Applications are invited for a postdoctoral researcher for 36 months to characterise the signalling pathways that regulate autophagy, lysosome exocytosis and biomolecular...
mRNA-based malaria vaccines, Paris, France The Malaria Parasite Biology and Vaccines Unit at Institut Pasteur (Prof. Chetan Chitnis), Paris announces a position for a post-doctoral fellow on a project to develop...
ABOUT SPEAKERS PROGRAMME REGISTRATION CONTACT LOCATION About the workshop ParaFrap is organizing the ParaFrap Next Generation in Parasitology...
Computational postdoctoral researcher in malaria and erythropoiesis, Montpellier, France The MIVEGEC Lab is seeking a highly motivated and talented postdoctoral researcher to join our team investigating the...
[Communiqué] As part of the actions of the Health Innovation Plan 2030, the health component of the France 2030 plan, Mohamed-Ali Hakimi is one of the 22 laureates of an Excellence Chair in Biology/Health, supported to conduct high-level research...
The York Biomedical Research Institute (YBRI) are hosting an online live seminar on Friday 24th May 1-2pm BST as part of their biomedical science seminar series. You are all welcome to attend - registration is required via the...
[Communiqué] Congratulations to Arthur Talman, IRD Research Leader in the MIVEGEC laboratory (Montpellier), who has been awarded an Advanced Grant from the European Research Council (ERC) for the project "TROJAN - Molecular mimicry and immune...
Ana Rita Gomes, a CNRS Research Associate at the Laboratory of Pathogens and Host Immunity in Montpellier, and former Postdoctoral fellow of the LabEx ParaFrap, has been awarded the prestigious CNRS Bronze Medal in 2023. This...
. PhD Opportunity, Tours, France Supervision Thesis Supervisor: Sonia LAMANDE; Co-Supervisor: Julie TOTTEY Project: FUNTIONAL CHARACTERISATION OF CYSTEINE CATHEPSINS IN THE APICOMPLEXAN PARASITE CRYPTOSPORIDIUM...
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