-
ABOUT
- Who are we
- Objectives of the LabEx
- Laboratories and teams
- Directory Board
- Industrial collaborators
- Institutional and Financial Supports
- GOVERNANCE
- Organigram
- Steering committee
- Executive Committee
- External Scientific Advisory Board
- Institutional Board
- TRAINING
- CONFERENCES
- PROJECTS
- Post genomic data exploration
- Mechanisms of pathogenesis
- Parasite molecular and cellular biology
- Towards new intervention strategies against parasitic pathogens
- Plateforms
- VALORIZATION
-
ABOUT
- Who are we
- Objectives of the LabEx
- Laboratories and teams
- Directory Board
- Industrial collaborators
- Institutional and Financial Supports
- GOVERNANCE
Gerald Spaeth received a ERC Synergy grant
[Communiqué]
Gerald Spaeth, head of the "Molecular Parasitology and Signalling" unit at the Institut Pasteur Paris, has been awarded a Synergy grant from the European Research Council (ERC) for the project "DECOLeishRN - Decoding epistatic genome/RNome interactions in ekaryotic fitness gain using Leishmania parasites as a unique model system". This project is funded at over 9 millions Euros and will be conducted in collaboration with two Israeli teams led by Shulamit Michaeli (Bar-Ilan University) and Yitzhak Pilpel (Weizmann Institute of Science).
Exploiting the unique biology of the protozoan parasite Leishmania as a model system, the project will generate unprecedented insight into the role of genome instability in eukaryotic adaptation by combining experimental evolution, analyses of the non-coding RNA, network modelling and cutting-edge, single cell sequencing. The project aims to uncover the molecular filter that can mitigate toxic effects of genome instability while promoting beneficial ones, thus resolving a long-standing question in infection and cancer biology.
The six-year project (2023-2029) is poised to reveal complex and dynamic interactions between genomic, epitranscriptomic and phenotypic adaptation of these important parasites, and the role of stress-adapted ribosomes and non-coding RNAs – especially anti-sense regulators – that compensate for detrimental gene dosage changes. The scientists will further examine whether the parasite has the capacity to predict and prepare in advance to changes in environmental conditions and the switch between its hosts. The study of pathogen evolution within a mammalian host will provide an innovative framework for the discovery of complex biomarker candidates linked to Leishmania virulence and drug resistance. Exploiting genome instability for adaptation is common to other diseases-causing microbes and cancer. This ERC Synergy grant will thus deliver a blueprint to study how chaotic genome instability is harnessed for adaptation and to escape unfavorable environmental conditions.
Friday, 06 October 2023Success for ParaFrap at MPM2023
Success for ParaFrap students at MPM2023 Parafrap students won numerous awards at the MPM 2023, Woods Hole USA, 17-21 September 2023. A warm congratulations to all ! Parul Sharma (2nd year PhD under the...
Thursday, 14 September 2023Predoc & Posdoc Offers l Plasmodium l Barcelona
Predoctoral and Postdoctoral positions - Barcelona, Spain Project Leader: Alfred Cortés, PhD - Barcelona Institute for Global Health Hospital Clínic - Universitat de Barcelona Positions: A predoctoral and two...
Thursday, 07 September 2023PhD Offer l Plasmodium/Schistosoma l Perpignan
PhD Position Perpignan, France Project Leader Ronaldo DE CARVALHO AUGUSTO (CPJ, UPVD), principal supervisor (50%) Jérôme BOISSIER (PU, UPVD), PI (50%) Project: Unveiling the Dark Secrets of Roommate Parasites: A Study...
Thursday, 07 September 2023PostDoc l Toxoplasma l California, USA
PostDoc position : Saeij Lab, Davis, California, USA The Saeij lab (https://saeijlab.faculty.ucdavis.edu/) at the University of California, Davis, is currently looking for several postdoctoral scholars to work on...
Wednesday, 06 September 2023PostDoc l Cryptosporidium l Tours, France
PostDoc position : Identify new repository molecules against Cryptosporidium, Tours, France The lab seeks to hire a highly motivated candidate to work on the identification of new repository molecules against...
Monday, 15 May 2023Emerging Leader Research Fellow - UK
Emerging Leader Research Fellow, Oxford Brookes University, UK The Oxford Brookes University offers an opportunity to develop an independent research group in molecular parasitology/protistology through a...
Wednesday, 05 April 2023PostDoc l P. falciparum l Montpellier
PostDoc position : Gene regulation/ DNA low complexity regions-DNA binding proteins, Montpellier, France The post-doc project aims to investigate the role of Low Complexity Regions in regulation of gene expression in P....
Monday, 03 April 2023Short Term Scientific Mission Grants
Short-Term Scientific Missions (STSMs) within the OneHealthdrugs (CA21111) network 1st CALL for applications 2023 The 1st STSM Call of the Action CA2111 OneHealthdrugs is launched. Short Term Scientific Mission...
Tuesday, 28 March 2023PostDoc l Immunity T. gondii l Lille
PostDoc position : Cross-talk between stress response and infection in dendritic cells at Institut Pasteur Lille, France We seek to hire a highly motivated candidate to work on the role of the Unfolded Protein...
Friday, 27 January 2023Nouvelles données sur l'invasion de Toxoplasma gondii
[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs moléculaires de l'invasion des bradyzoïtes et...
TRAINING PROGRAM
International PhD ProgramPostdoctoral ProgramNEWS
© 2023. All rights reserved MLCOM
Notre site LabEx ParaFrap utilise des cookies pour réaliser des statistiques de visites, partager des contenus sur les réseaux sociaux et améliorer votre expérience. En refusant les cookies, certains services seront amenés à ne pas fonctionner correctement. Nous conservons votre choix pendant 30 jours. Vous pouvez changer d'avis en cliquant sur le bouton 'Cookies' en bas à gauche de chaque page de notre site. En savoir plus
Cookies settings
×Functional Cookies
Ce site utilise des cookies pour assurer son bon fonctionnement et ne peuvent pas être désactivés de nos systèmes. Nous ne les utilisons pas à des fins publicitaires. Si ces cookies sont bloqués, certaines parties du site ne pourront pas fonctionner.
Measure of audience
Ce site utilise des cookies de mesure et d’analyse d’audience, tels que Google Analytics et Google Ads, afin d’évaluer et d’améliorer notre site internet.
- Google Analytics
- Google Ads
Interactive Content
Ce site utilise des composants tiers, tels que NotAllowedScript6575f31c9f50aReCAPTCHA, Google NotAllowedScript6575f31c9f07fMaps, MailChimp ou Calameo, qui peuvent déposer des cookies sur votre machine. Si vous décider de bloquer un composant, le contenu ne s’affichera pas
- Google Maps
Pour en savoir plus, cliquez sur le lien.
See the official site - Calameo
Pour en savoir plus, cliquez sur le lien.
See the official site - reCaptcha V2
Pour en savoir plus, cliquez sur le lien.
See the official site - reCaptcha V3
Pour en savoir plus, cliquez sur le lien.
See the official site
Social Networks / Videos
Des plug-ins de réseaux sociaux et de vidéos, qui exploitent des cookies, sont présents sur ce site web. Ils permettent d’améliorer la convivialité et la promotion du site grâce à différentes interactions sociales.
- Twitter
Pour en savoir plus, cliquez sur le lien.
See the official site
Session
Please login to see yours activities!Other cookies
Ce site web utilise un certain nombre de cookies pour gérer, par exemple, les sessions utilisateurs.
