French Alliance for Parasitology and Health Care

The Apicolipid team, ParaFrap member (Institute for Advanced Biosciences, CNRS/Inserm/ Université Grenoble Alpes), with researchers from the University of Melbourne, has just published two studies in Cell Microbiology and PLOS Pathogens. These studies show that to survive, the parasites responsible for malaria and toxoplasmosis depend on mechanisms inherited from the plant world. This discovery is a major advance for the development of new therapeutic targets for these parasites, which have such substantial public health consequences.

Find the press releases HERE.

Bibliography :

Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast, Shears MJ, MacRae JI, Mollard V, Goodman CD, Sturm A, Orchard LM, Llinás M, McConville MJ, Botté CY*, McFadden GI*. Cell Microbiology, 20 juin 2016. Link

Apicoplast-localized lysophosphatidic acid precursor assembly is required for bulk phospholipid synthesis in Toxoplasma gondii and relies on an algal/plant-like glycerol 3-phosphate acyltransferase, Amiar S, MacRae JI, Callahan DL, van Dooren GG, Shears MJ, Dubois D, Cesbron-Delauw MF, Maréchal E, McConville MJ, McFadden GI, Yamaryo-Botté Y*, Botté CY*. PLOS Pathogens, 4 août 2016. Link

The 2nd ParaFrap conference will take place on October 2-5, 2016, « Île des Embiez » (South of France). Our conference is now fully booked. If you would still like to attend, kindly enter your details on our waiting list on . We will notify you immediately if we receive any cancellations.

The conference features 7 internationally renowned keynote speakers : Carolina Barillas-Mury (NIH, USA), Keith Matthews (University of Edinburgh, UK), Malcolm McConville (Université of Melbourne, Australia), Marc Ouellette (University Laval, Canada), Ellen Robey (Université of California, USA), Boris Striepen (Université of Georgia, USA) et Andy Waters (University of Glasgow, UK).

There will be opportunities for participants to present both talks and posters (selected from abstracts).

The conference fees cover the meeting attendance, accommodation, meals, gala dinner and coffee breaks.

Registration fees (including VAT)


300 €

Senior scientists

420 €


975 €

More détails on

After an international call and a highly selective process, ParaFrap recruited 11 new PhD students and 8 new post-docs. They will enroll the Doctoral or Post-Doctoral programs in October, 2016.

Find below the list of selected candidates :

PhD Students

Selected Candidates

PIs Institutions Topics
Cyrille Botté
(& Y. Yamaryo-Botté)
 University Grenoble Alpes

Membrane biogenesis in Toxoplasma gondii: Characterization of novel enzymes responsible for the lipid processing pathway.

Du Manoir

Antoine Berry
(N. Blanchard's group)

 University Toulouse III Paul Sabatier, Toulouse  Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in Central Africa: new insight from the field to the atom
Mohamed-Ali Hakimi

University Grenoble Alpes

Uncovering the function of two apicomplexan-specific histone acetylation marks located at the nucleosome dyad in both Toxoplasma and Theileria


Salah Mécheri
(A. Scherf's group)

Pasteur  Institute, Paris

Investigation of the protective response against pre erythrocytic stages of malaria parasite in hosts with induced liver inflammation

Jose-Juan Lopez-Rubio  University of Montpellier

 G-Quadruplexes - mediated regulation of Plasmodium falciparum virulence 

Mélanie Bonhivers
(D. Robinson's group)
 University of Bordeaux  Detailed analysis and study of the biogenesis of the trypanosome FPC cytoskeleton
Elisabeth Davioud-Charvet  University of Starsbourg  Development of a selective activity-based probe for NADPH-dependent flavoproteome analysis in malarial parasites
Olivier Silvie  UPMC, Universités Sorbonne, Paris

Role of host receptors during Plasmodium and Toxoplasma host cell invasion

Maryse Lebrun  University of Montpellier Characterization of host Moving Junction Partners involved in invasion of Apicomplexan parasites


Frédéric Bringaud

University of Bordeaux Role of the unusual peroxisomal/glycosomal sequestration of cytosolic metabolic pathways in trypanosomes
Sterkers Yvon
(P. Bastien's group)
University of
Unravelling the molecular processes leading to flexible gene dosage by mosaic aneuploidy in Leishmania.



Selected Candidates

PIs Institutions Topics
Maryse Lebrun  University of Montpellier

Functional characterization of rhoptry secretion mechanisms in Plasmodium and Toxoplasma

Batista Gomes
Anna Rita

Jose-Juan Lopez-Rubio

 University of Montpellier Development of new CRISPR-Cas9 tools to study malaria parasite virulence mechanisms
Artur Scherf Pasteur Institute, Paris

Role of cis genetic elements in monoallellic expression of Plasmodium falciparum


Olivier Silvie

UPMC, Paris

Functional characterization of Plasmodium sporozoite transient vacuoles

Mohamed-Ali Hakimi  University Grenoble Alpes

Identification of new compounds with activity against Toxoplasma gondii and Plasmodium. Applications to develop new anti-parasitic agents directed to novel targets.

Cyrille Botté  University Grenoble Alpes  Plasmodium falciparum: Characterization of novel enzymes responsible for the lipid processing pathway
Marie-France Cesbron-Delauw  University Grenoble-Alpes  Identifying parasite gene(s) triggering resistance to toxoplasmosis in the rat model
Gordon Langsley  CNRS, INSERM, University Paris Descartes

EHMT1-mediated gene silencing in virulent Theileria-infected macrophages





Dr Maryse Lebrun, a LabEx ParaFrap partner, is the laureate for the Jacques Piraud Price of the 2015 FRM (Fondation pour la Recherche Médiacale) Scientific Price, that rewards research on infectious diseases, for her work on the molecular mechanisms that enable Toxoplama gondii parasites enter their host cells and then multiply.

Press release and ceremony pictures


Amandine Guérin and Lauriane Sollelis, PhD students of ParaFrap, were awarded the best poster prize for their work presented at the "2015 (26th) Annual Molecular Parasitology Meeting" (Woods Hole, USA). Two out of the six laureates, among 150 posters, are from our LabEx. Congratulations !!

Find out more about these posters, visit the MPM2015 conference website (see "2015 abstract book").

Page 9 of 10


International PhD Program


LabEx News
Other News



Project Manager: Yoann MILLERIOUX

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