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Alliance Française contre les Maladies Parasitaires

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Les Dr. Mohamed-Ali Hakimi et Cyrille Botté, partenaires du LabEx ParaFrap, ont reçu le Label Equipe FRM 2021 (Fondation pour la Recherche Médicale). Cette bourse permet d'apporter un soutien fort et durable à des équipes proposant des programmes de recherche innovants en biologie avec des applications potentielles en santé.


Le projet du Dr. Mohamed-Ali Hakimi et son équipe propose d'étudier des traitements alternatifs de la Toxoplasmose et des maladies médiées par les parasites apicomplexes.

Le projet proposé par l'équipe du Dr Cyrille Botté ambitionne de comprendre l'adaptation métabolique et lipidique des parasites apicomplexes à l'environnement nutritionnel de leur hôte

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pdfListe des dossiers sélectionnés en 2021




Le LabEx ParaFrap vous présente ses meilleurs voeux pour cette nouvelle année et vous souhaite de trouver la joie, la santé et les succés !

HNY 2021


Le projet « ROS killers » de l''équipe du Dr Elisabeth Davioud-Charvet a été financé par EUCOR – Le Campus européen. Il implique une collaboration de 5 équipes de 3 universités : Strasbourg – Mulhouse – Bâle adossée à un réseau de collaborations européennes, fédérateur sur le projet de chimie médicinale rédox pour lutter contre les maladies parasitaires tropicales « redox-CURE-TPDs ».

Plus d'information :


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Please note : The date at which shortlisted candidates will be invited for the final interview process has been postponed to the 10th May. These final interviews will take place online on the 21-22-23rd June 2021. 

The international PhD program of the French national research project 'ParaFrap' is currently open for applications for 17 Ph.D. positions to be started in October 2021.


The LabEx (Laboratory of Excellence) ParaFrap is a Health Sciences collaborative research program focusing on Molecular and Cellular Parasitology in its wider sense. The network gathers 26 French leading groups in the field and is funded by the Excellence Initiative of the French Ministry of Research. Four major research fields are investigated in protozoan models such as PlasmodiumToxoplasmaLeishmaniaTrypanosoma and Cryptosporidium:

Ø  Post-genomic data exploration
Ø  Mechanisms of pathogenesis and protective immunity
Ø  Parasite molecular and cellular biology
Ø  Towards new intervention strategies against parasitic pathogens

The ParaFrap International Ph.D. program is an ambitious program offering competitive Ph.D. grants to high-quality students/early stage scientists. Applications are open to non-French students. The early stage scientists will be joining research projects selected by an external scientific board and managed by a main supervisor and a co-supervisor from two distinct research groups of the LabEx. These core research projects will focus on the use of state-of-the-art post-genomic tools to enhance knowledge of the parasites' biology and of their interactions with their hosts. We are committed to providing ParaFrap Ph.D. students with the best starting platform for a successful career in science. Additional information about ParaFrap can be found on


Eligibility requirements

1. Applicants must have achieved academic excellence and be highly motivated to pursue a Ph.D. project in Parasitology. They should have obtained a 'Masters 2' degree or an equivalent (5 years after high/secondary school) in science by July 2021; out of this format, only exceptional applications (upon justification) will be considered by the program director.

2. English language skills are mandatory.

3. The PhD program does not have an age restriction, but most accepted candidates are 24-26 years old and start their Ph.D. within a year of finishing their M.Sc., a few of them within 3 years.

4. Mobility between the Master's lab and the Ph.D. host lab is mandatory, meaning that the applicants must change from their present Research Director and Institute to another for the Ph. D. training.


The deadline for submitting an application is on the 10th April 2021.

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PhD research projects


How does T. gondii modulate neuronal responses and antigen presentation to evade immune recognition throughout chronic infection?


Characterization of a central transcriptional regulator for the metabolic adaptation of Toxoplasma towards its host

Cyrille BOTTÉ

Role(s) of glycerol metabolism in the biology of African trypanosomes


Role of a host peroxiredoxin in blood stage growth of malaria parasites


How do parasites manipulate the behaviour of their vectors? A comparative spatial transcriptomic study in Anopheles and Glossina sensory organs.


Optimisation of antiparasitic redox-active 3-benzylmenadiones and of drug partners for effective drug combination by oral administration



Study of in vivo P. vivax and falciparum – host bone marrow interactions


The molecular drivers of antigenic variation in African Trypanosomes


The Epigenetic Role(s) of MORC-containing Complexes Operating in the Hidden Face of the T. gondii Life Cycle or Regulating Virulence Genes in the Human Malaria Parasite

Mohamed-Ali HAKIMI

PfPP1 contribution to egress in asexual and sexual stages of the malaria parasite Plasmodium falciparum


Identification of curative treatments to control cryptosporidiosis and the associated molecular mechanism


Deciphering how erythroblast infection by Plasmodium falciparum induces a delay in erythropoiesis

Catherine LAVAZEC

Studying two complementary infection models to identify common mechanisms of intracellular parasite survival: The roles of Leishmania and Eimeria exo-kinases in subversion of host cell signalling.


DevDermTryp – Development of dermal trypanosomes


Targeting a Plasmodium propeller domain protein to prevent malaria liver stage infection

Olivier SILVIE

Unravelling the role of epigenetic factors which control the DNA replication in Leishmania


How does a Toxoplasma gondii bradyzoite cope with the small intestine surface biochemical, topographical and rheological properties to colonize the enterocytes



Information about the PhD research projects, selection process, as well as the application procedure, is available at  https://parafrap.application.systemsAll applications MUST be made online on this website.

Successful applicants will be enrolled in one of the 17 research groups who were awarded a Ph.D. fellowship, distributed among diverse French Universities (see website). Each applicant will have to indicate 4 projects of interest. If selected, he/she should be enrolled in one of the four projects indicated, unless the selection committee sees a particular interest in modifying one of his/her options.


       Pre-selectionApplicants will be selected by a committee formed by group leaders of each of the participating laboratories, based on the high standards used at EMBL, including academic achievements, previous experience in research, and (blind) letters of recommendation. Each PI will rank five applicants according to his/her CV, academic records, laboratory experience and letters of recommendation from referees.

       Interviews: The ParaFrap selection committee will then invite a shortlist of 35-40 candidates for the final selection round, i.e. interviews in front of the whole panel of PIs of the programme. These interviews will take place between June 15th and June 23rd at Institut Pasteur in Paris or remotely by video, depending on the pandemic situation. If on site, travel and accommodation expenses will be covered by ParaFrap.

       Final selection: After ranking by the selection committee, letters of acceptance will be sent immediately to the top 17 candidates, who will be asked to give their approval in the following week. The remaining candidates will be informed of their ranking. Should a candidate refuse the offer, the first candidate in the waiting list will receive a letter of acceptance.


The PhD. student will be supervised by his/her thesis supervisor and the main collaborator (‘co-PI’) in the projectwho has to be from another institute. A Ph.D. thesis committee will interview the student at the end of the 1st and 2nd year and produce a mid-report to the Doctoral School of the University.


       Duration: The selected Ph.D. students will be recruited on a fixed-term contract of 36 months.

    Studentship: The maximum gross monthly salary will be 2500 €, depending on the Research Institutions. The Ph.D. students will receive private health insurance and social security entitlements.

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PhD Program provisional planning

April 10th, 2021 Application deadline
April  15th, 2021 Referees deadline (blind letters of recommendation)
May 10th 2021 Invitations for interviews sent to applicants
June 21st-23rd, 2021 Interviews  and notification of the results
June 30th, 2021 Definitive acceptance by the selected applicants
September 1st, 2021 Start of the Ph.D.




En raison de la situation sanitaire liée à l'épidémie de COVID-19 et des incertitudes, le EMBO Workshop : New frontiers in host-parasite interactions, from cell to organism initialement prévu du 4 au 7 octobre 2020 est reporté du 3 au 6 octobre 2021, sur l'ile des Embiez dans le sud de la France. Ce workshop ouvert à tous est soutenu par EMBO et ParaFrap, aura pour but de promouvoir les interactions et les discussions entre chercheurs, en particulier avec les jeunes scientifiques.

Les détails et le programme vous seront dévoilés prochainement. 

En attendant, cliquez-ici pour entrer votre adresse e-mail et être averti lors de l'ouverture du site web de l'évènement, et suivre notre fil Twitter @ParaFrap pour rester informé.

Le workshop abordera les dernières avancées en matière d'interaction hôte-parasite au niveau de la cellule, des tissus et des organismes, avec des sessions sur les manipulations de l'hôte et les stratégies d'évitement, les réponses immunitaires et la pathogenèse de l'hôte, la biologie des cellules parasitaires, la biologie moléculaire du parasite et la signalisation, les réservoirs et niches parasitaires, les stratégies de vaccination et de lutte. Le workshop couvrira plusieurs parasites protozoaires (Plasmodium, Toxoplasma, Cryptosporidium, Trypanosoma, Leishmania) et offre une occasion exceptionnelle de partager des connaissances scientifiques de pointe.

Le workshop comprendra des sessions posters et des turbo-talks, offrant aux jeunes chercheurs l'occasion de présenter leurs travaux, dans environnement stimulant.