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ABOUT
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Press release - LCBM/Anopheles Teams
Molecules that target both malaria infection and transmission ... Because they are linked to a steroid, new molecules derived from ortho-aminocresols, already known for their antimalarial action, prove to be more effective in killing the parasite in the infected host, but also to block its transmission. This work, published in Nature Communications, is the result of a multidisciplinary and international collaboration led by German researchers (universities of Jena and Giessen) and French members of ParaFrap (Elisabeth Davioud-Charvet - Molecular Chemistry Laboratory, Institute of Biology Molecular and cellular CNRS with the collaboration of the laboratory of Stéphanie Blandin - Inserm "Immune response in the Anopheles mosquito vector of malaria" of Strasbourg). This work shows that for their survival, the parasites responsible for malaria and toxoplasmosis depend on mechanisms inherited from the plant world. This discovery represents a major advance in the development of new therapeutic targets against these parasites with major public health consequences.
This work has been the subject of numerous press releases, which you can find HERE.
Référence :
Arylmethylamino steroids as antiparasitic agents. Krieg, R., E. Jortzik, A. A. Goetz, S. Blandin, S. Wittlin, M. Elhabiri, M. Rahbari, S. Nuryyeva, K. Voigt, H. M. Dahse, A. Brakhage, S. Beckmann, T. Quack, C. G. Grevelding, A. B. Pinkerton, B. Schonecker, J. Burrows, E. Davioud-Charvet, S. Rahlfs and K. Becker (2017). Nat Commun 8: 14478. Link
Monday, 09 June 2025PostDoc l Trypanosoma l Bordeaux, FR
Postdoc (M/F) Molecular and cell biology in Trypanosoma brucei A 24-month post-doctoral position starting on November 1st 2025 (or before) and funded by the French National Research Agency (ANR) is available in the...
Wednesday, 04 June 2025PostDoc l Plasmodium l Montpellier, FR
Postdoc (M/F) in molecular biology in P. falciparum Workplace: MONTPELLIER Contract Period: 24 months Expected date of employment: 1 October 2025 Proportion of work: Full Time Remuneration: Starting from...
Friday, 25 April 2025EMBO Workshop Host Parasite 2025 - Registration
Registration is now open for the EMBO Workshop "Host-Parasite Relationship: From Mechanisms to Control Strategies," supported by...
Tuesday, 11 March 2025Associate professor l Toxoplama l Bordeaux, France
Associate Professor : Animal Biology and Parasitology – Host-Pathogen Interactions, Bordeaux, France Teaching Profile The candidate will teach in animal biology, especially in metazoan diversity, phylogeny,...
Wednesday, 26 February 2025EMBO Workshop Host Parasite 2025
The EMBO Workshop "Host-parasite relationship: from mechanisms to control strategies", supported by ParaFrap, will take place from...
Wednesday, 05 February 2025ParaFrap Webinar - Gretchen DIFFENDALL
ParaFrap Webinar Thursday, February 13, 2025 at 15:00 (CET) Gretchen...
Tuesday, 14 January 2025PostDoc x2 l Trypanosoma l Lisbon, PT
Two PostDoc positions on Trypanosoma brucei and its interactions with blood vessels, Lisbon, Portugal A collaborative project in the Lisbon area, Portugal, to explore groundbreaking interactions between...
Thursday, 24 October 2024PostDoc l Trypanosoma l Paris, FR
Postdoctoral position, Institut Pasteur, Paris, France A 24-month post-doctoral position starting on March 1st 2025 and funded by the French National Research Agency (ANR) is available in the Trypanosome...
Monday, 21 October 2024PostDoc x2 l Malaria l Montpellier, FR
Postdoctoral positions, LPHI Lab, Montpellier, France Two ERC-funded (JANUS 2024-2029) postdoc positions are open in the lab to study cell cycle regulation in malaria...
Tuesday, 01 October 2024PostDoc l Leishmania l Paris, FR
Postdoctoral position, Institut Pasteur, Paris, France A postdoc position is available at the Institut Pasteur Paris, in the signalling and host-parasite interactions research group, headed by Dr Najma Rachidi...
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