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ABOUT
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Press release - LCBM/Anopheles Teams
Molecules that target both malaria infection and transmission ... Because they are linked to a steroid, new molecules derived from ortho-aminocresols, already known for their antimalarial action, prove to be more effective in killing the parasite in the infected host, but also to block its transmission. This work, published in Nature Communications, is the result of a multidisciplinary and international collaboration led by German researchers (universities of Jena and Giessen) and French members of ParaFrap (Elisabeth Davioud-Charvet - Molecular Chemistry Laboratory, Institute of Biology Molecular and cellular CNRS with the collaboration of the laboratory of Stéphanie Blandin - Inserm "Immune response in the Anopheles mosquito vector of malaria" of Strasbourg). This work shows that for their survival, the parasites responsible for malaria and toxoplasmosis depend on mechanisms inherited from the plant world. This discovery represents a major advance in the development of new therapeutic targets against these parasites with major public health consequences.
This work has been the subject of numerous press releases, which you can find HERE.
Référence :
Arylmethylamino steroids as antiparasitic agents. Krieg, R., E. Jortzik, A. A. Goetz, S. Blandin, S. Wittlin, M. Elhabiri, M. Rahbari, S. Nuryyeva, K. Voigt, H. M. Dahse, A. Brakhage, S. Beckmann, T. Quack, C. G. Grevelding, A. B. Pinkerton, B. Schonecker, J. Burrows, E. Davioud-Charvet, S. Rahlfs and K. Becker (2017). Nat Commun 8: 14478. Link
Thursday, 24 October 2024PostDoc l Trypanosoma l Paris, FR
Postdoctoral position, Institut Pasteur, Paris, France A 24-month post-doctoral position starting on March 1st 2025 and funded by the French National Research Agency (ANR) is available in the Trypanosome...
Monday, 21 October 2024PostDoc x2 l Malaria l Montpellier, FR
Postdoctoral positions, LPHI Lab, Montpellier, France Two ERC-funded (JANUS 2024-2029) postdoc positions are open in the lab to study cell cycle regulation in malaria...
Tuesday, 01 October 2024PostDoc l Leishmania l Paris, FR
Postdoctoral position, Institut Pasteur, Paris, France A postdoc position is available at the Institut Pasteur Paris, in the signalling and host-parasite interactions research group, headed by Dr Najma Rachidi...
Monday, 01 July 2024Next Generation In Parasitology - Workshop
ABOUT SPEAKERS PROGRAMME REGISTRATION CONTACT LOCATION About the workshop ParaFrap is organizing the ParaFrap Next Generation in Parasitology...
Monday, 29 April 2024MA. Hakimi, laureate of the Excellence Chair in Biology/Health France 2030
[Communiqué] As part of the actions of the Health Innovation Plan 2030, the health component of the France 2030 plan, Mohamed-Ali Hakimi is one of the 22 laureates of an Excellence Chair in Biology/Health, supported to conduct high-level research...
Tuesday, 16 April 2024Seminar - Boris Striepen - May 24
The York Biomedical Research Institute (YBRI) are hosting an online live seminar on Friday 24th May 1-2pm BST as part of their biomedical science seminar series. You are all welcome to attend - registration is required via the...
Friday, 12 April 2024Arthur Talman received an ERC Advanced grant
[Communiqué] Congratulations to Arthur Talman, IRD Research Leader in the MIVEGEC laboratory (Montpellier), who has been awarded an Advanced Grant from the European Research Council (ERC) for the project "TROJAN - Molecular mimicry and immune...
Wednesday, 13 March 2024CNRS Bronze Medal for Ana Rita GOMES
Ana Rita Gomes, a CNRS Research Associate at the Laboratory of Pathogens and Host Immunity in Montpellier, and former Postdoctoral fellow of the LabEx ParaFrap, has been awarded the prestigious CNRS Bronze Medal in 2023. This...
Sunday, 07 January 2024Webinars 2024
Happy New Year 2024! To kick off this new scientific year, here is the ParaFrap webinar schedule. Since January 2021, ParaFrap has been organizing a series of webinars. This monthly event, held every 2nd Thursday of the month, aims to strengthen...
Wednesday, 13 December 2023New method to produce in vitro Toxoplasma pre-gametes
The team of Dr. Mohamed-Ali Hakimi, in collaboration with Isabelle Coppens (Johns Hopkins University Bloomberg School of Public Health and Malaria Research Institute, Baltimore, MD, USA), has developed a new (epi)genetic method to produce in vitro...
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