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Alliance Française contre les Maladies Parasitaires


  JJ Lopez Rubio



microscope Laboratory of Pathogen-Host Interactions (LPHI), UMR5235 
team Plasmodium DNA biology 
location Montpellier
orcid 0000-0002-0555-1122 
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Scientific interests and projects

Our team uses cutting edge technologies to understand DNA biology in Plasmodium falciparum, a unicellular eukaryotic parasite that causes the most severe form of malaria in humans. Given the tight regulation of gene expression in malaria parasites, the apparent paucity of transcription-associated factors is surprising and points to existence of divergent regulatory pathways. Our projects investigate two emerging mechanisms for gene regulation, non coding RNA and G4-quadruplex DNA secondary structures. Such divergent regulatory mechanisms present ideal drug targets that may be explored for new antimalarial strategies.