Jose-Juan |
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Information |
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Laboratory of Pathogen-Host Interactions (LPHI), UMR5235 | ||
Plasmodium DNA biology | ||
Montpellier | ||
0000-0002-0555-1122 | ||
This email address is being protected from spambots. You need JavaScript enabled to view it. | ||
https://lphi.umontpellier.fr/en/lphi-teams/plasmodium-genome-plasticity | ||
Scientific interests and projects |
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Our team uses cutting edge technologies to understand DNA biology in Plasmodium falciparum, a unicellular eukaryotic parasite that causes the most severe form of malaria in humans. Given the tight regulation of gene expression in malaria parasites, the apparent paucity of transcription-associated factors is surprising and points to existence of divergent regulatory pathways. Our projects investigate two emerging mechanisms for gene regulation, non coding RNA and G4-quadruplex DNA secondary structures. Such divergent regulatory mechanisms present ideal drug targets that may be explored for new antimalarial strategies. |
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Top 5 publications of the last 5 years |
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1. Lee MCS, Lindner SE, Lopez-Rubio JJ, Llinas M. Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium. Brief Funct Genomics. 2019 Jul 29. pii: elz012. doi: 10.1093/bfgp/elz012 2. Belmonte-Reche E, Martínez-García M, Guédin A, Zuffo M, Arévalo-Ruiz M, Doria F, Campos-Salinas J, Maynadier M, López-Rubio JJ, Freccero M, Mergny JL, Pérez-Victoria JM, Morales JC. G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents. J Med Chem. 2018 Feb 8;61(3):1231-1240. doi: 10.1021/acs.jmedchem.7b01672 3. Sollelis L, Ghorbal M, MacPherson CR, Martins RM, Kuk N, Crobu L, Bastien P, Scherf A, Lopez-Rubio JJ, Sterkers Y. First efficient CRISPR-Cas9-mediated genome editing in Leishmania parasites. Cell Microbiol. 2015 Oct;17(10):1405-12. doi: 10.1111/cmi.12456 4. Mbengue A, Bhattacharjee S, Pandharkar T, Liu H, Estiu G, Stahelin RV, Rizk SS, Njimoh DL, Ryan Y, Chotivanich K, Nguon C, Ghorbal M, Lopez-Rubio JJ, Pfrender M, Emrich S, Mohandas N, Dondorp AM, Wiest O, Haldar K. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature. 2015 Apr 30;520(7549):683-7. doi: 10.1038/nature14412 5. Ghorbal M, Gorman M, Macpherson CR, Martins RM, Scherf A, Lopez-Rubio JJ. Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPRCas9 system. Nat Biotechnol. 2014 Aug;32(8):819-21. doi: 10.1038/nbt.2925 |
The York Biomedical Research Institute (YBRI) are hosting an online live seminar on Friday 24th May 1-2pm BST as part of their biomedical science seminar series. You are all welcome to attend - registration is required via the...
[Communiqué] Congratulations to Arthur Talman, IRD Research Leader in the MIVEGEC laboratory (Montpellier), who has been awarded an Advanced Grant from the European Research Council (ERC) for the project "TROJAN - Molecular mimicry and immune...
Ana Rita Gomes, a CNRS Research Associate at the Laboratory of Pathogens and Host Immunity in Montpellier, and former Postdoctoral fellow of the LabEx ParaFrap, has been awarded the prestigious CNRS Bronze Medal in 2023. This...
. PhD Opportunity, Tours, France Supervision Thesis Supervisor: Sonia LAMANDE; Co-Supervisor: Julie TOTTEY Project: FUNTIONAL CHARACTERISATION OF CYSTEINE CATHEPSINS IN THE APICOMPLEXAN PARASITE CRYPTOSPORIDIUM...
Senior PostDoc position : computational biologist, Paris, France The ParSig team (https://research.pasteur.fr/en/team/molecular-parasitology-and-signaling) at the Institut Pasteur in Paris seeks for a highly...
Researcher in Livestock Immunology for the Study of Animal Trypanosomoses Through a One Health approach, the Intertryp Joint Research Unit (Cirad-IRD) is developing research on interactions between hosts,...
Happy New Year 2024! To kick off this new scientific year, here is the ParaFrap webinar schedule. Since January 2021, ParaFrap has been organizing a series of webinars. This monthly event, held every 2nd Thursday of the month, aims to strengthen...
PostDoc position : functional analysis of P. falciparum early gametocyte proteins, Allschwil, Switzerland The Malaria Gene Regulation Lab of Till Voss is looking for a highly motivated and talented postdoc to...
The team of Dr. Mohamed-Ali Hakimi, in collaboration with Isabelle Coppens (Johns Hopkins University Bloomberg School of Public Health and Malaria Research Institute, Baltimore, MD, USA), has developed a new (epi)genetic method to produce in vitro...
Success for ParaFrap students at MPM2023 Parafrap students won numerous awards at the MPM 2023, Woods Hole USA, 17-21 September 2023. A warm congratulations to all ! Parul Sharma (2nd year PhD under the...
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