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Alliance Française contre les Maladies Parasitaires


 

  Gerald Spaeth

 

Gerald SPAETH

Information

microscope Departement of Parasite and Insect vectors 
team Molecular Parasitology and Signaling 
location Bordeaux
orcid 0000-0002-0256-2029 
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website https://research.pasteur.fr/en/team/molecular-parasitology-and-signaling/

Scientific interests and projects

The unit ‘Molecular Parasitolgy and Signaling’ conducts multidisciplinary and internationally highly visible research on Leishmania/macrophage interaction and co-evolution. Our program analyses Leishmania and macrophage regulatory pathways implicated in intracellular parasite development and subversion of host cell functions that qualify as novel drug targets.

We will pursue three main axes as part of the ParaFrap consortium:

Axis 1 investigates mechanisms of Leishmania differentiation and evolutionary adaptation by conducting systems level and comparative genomics analyses of hamster-derived parasites and clinical isolates with the aim to identify genetic loci that are linked to Leishmania fitness gain in culture and in infected animals;

Axis 2 analyses the signalling role of the Leishmania ecto-kinase CK1.2 and its role in subversion of host cell immune signalling, with the aim to target its exosomal release for anti-leishmanial therapy;

Axis 3 studies mechanisms of Leishmania host subversion using immunological, pharmacological and systems-level investigations, with the aims to (i) discover host-directed, anti-leishmanial hits and (ii) study the impact of intracellular Leishmania infection on macrophage epigenetic regulation, phenotype and functions. Together these three axes provide important added value to the main ParaFrap scientific work packages, including WP1 on post genomic data exploration (Axes 1 – 3), WP2 on mechanisms of pathogenesis and anti-parasite immunity (Axes 2 and 3), WP3 on parasite molecular and cellular biology (Axes 1 and 3), and WP4 on development of new intervention strategies against parasitic pathogens (Axes 2 and 3).