Project Title : "Synthesis of chemical tools for tracking lead antiparasitic drugs and their metabolites generated in targeted parasites by nanoSIMS- and fluorescence confocal- imaging & metabolomics"

Project PI : Elisabeth Davioud-Charvet Co-PI : Stéphanie Blandin

Thesis defense : 11/07/2017 

Lab : Laboratoire de Chimie Bioorganique et Médicinale, Strasbourg  

POSITION AFTER PARAFRAP TRAINING

Postdoctoral researcher in Guangzhou, China

PUBLICATIONS

Cichocki, B.A., Donzel, M., Heimsch, K.C., Lesanavičius, M., Feng, L., Montagut, E.J., Becker, K., Aliverti, A., Elhabiri, M., Čėnas, N., Davioud-Charvet, E., (2021). Plasmodium falciparum Ferredoxin-NADP+ Reductase-Catalyzed Redox Cycling of Plasmodione Generates Both Predicted Key Drug Metabolites: Implication for Antimalarial Drug Development. ACS Infect Dis [4.6] doi: 10.1021/acsinfecdis.1c00054

Feng, L., Pomel, S., Latre de Late, P., Taravaud, A., Loiseau, P.M., Maes, L., Cho-Ngwa, F., Bulman, C.A., Fischer, C., Sakanari, J.A., Ziniel, P.D., Williams, D.L., Davioud-Charvet, E., (2020). Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections. Molecules [3.3] 25, 5075. doi: 10.3390/molecules25215075

Feng, L., D. A. Lanfranchi, L. Cotos, E. Cesar-Rodo, K. Ehrhardt, A.-A. Goetz, H. Zimmermann, F. Fenaille, S. A. Blandin and E. Davioud-Charvet (2018). "Synthesis of plasmodione metabolites and 13C-enriched plasmodione as chemical tools for drug metabolism investigation." Org Biomol Chem [3.6] 16(15): 2647-2665. [Link]

Rodo, E. C., L. Feng, M. Jida, K. Ehrhardt, M. Bielitza, J. Boilevin, M. Lanzer, D. L. Williams, D. A. Lanfranchi and E. Davioud-Charvet (2016). "A Platform of Regioselective Methodologies to Access Polysubstituted 2-Methyl-1,4-naphthoquinone Derivatives: Scope and Limitations." European Journal of Organic Chemistry [3.1] 2016(11): 1982-1993 . [Link]