Alliance Française contre les Maladies Parasitaires


Project Title : "Investigations on the mechanisms of hypnozoite quiescence and activation in the malaria parasites Plasmodium vivax & P. cynomolgi"

Project PI : Dominique Mazier  Co-PI : Artur Scherf

Thesis defense : 01/12/2016

Lab : Malaria: identification and pre-clinical validation of novel therapeutics, CIMI, Paris

Background :

  • Business Foundation Certificate, INSEA - France (2017)
  • Doctor in Industrial Pharmacy, University of Messina - Italy (2006-2011) 

Position after ParaFrap training : Postodoctoral researcher in Artur Scherf Lab, Pasteur Institute, Paris - France

Publications :

Zanghi, G., S. S. Vembar, S. Baumgarten, S. Ding, J. Guizetti, J. M. Bryant, D. Mattei, A. T. R. Jensen, L. Renia, Y. S. Goh, R. Sauerwein, C. C. Hermsen, J. F. Franetich, M. Bordessoulles, O. Silvie, V. Soulard, O. Scatton, P. Chen, S. Mecheri, D. Mazier and A. Scherf (2018). "A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection." Cell Rep [8.3] 22(11): 2951-2963. [Pubmed]

Cubi, R., S. S. Vembar, A. Biton, J. F. Franetich, M. Bordessoulles, D. Sossau, G. Zanghi, H. Bosson-Vanga, M. Benard, A. Moreno, N. Dereuddre-Bosquet, R. Le Grand, A. Scherf and D. Mazier (2017). "Laser capture microdissection enables transcriptomic analysis of dividing and quiescent liver stages of Plasmodium relapsing species." Cell Microbiol [4.5] 19(8). [Pubmed]

Chen, P. B., S. Ding, G. Zanghi, V. Soulard, P. A. DiMaggio, M. J. Fuchter, S. Mecheri, D. Mazier, A. Scherf and N. A. Malmquist (2016). "Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites." Sci Rep [5.2] 6: 21802. [Pubmed]

Barata, L., P. Houze, K. Boutbibe, G. Zanghi, J. F. Franetich, D. Mazier and J. Clain (2016). "In Vitro Analysis of the Interaction between Atovaquone and Proguanil against Liver Stage Malaria Parasites." Antimicrob Agents Chemother [4.5] 60(7): 4333-4335. [Pubmed]

Soulard, V., H. Bosson-Vanga, A. Lorthiois, C. Roucher, J. F. Franetich, G. Zanghi, M. Bordessoulles, M. Tefit, M. Thellier, S. Morosan, G. Le Naour, F. Capron, H. Suemizu, G. Snounou, A. Moreno-Sabater and D. Mazier (2015). "Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice." Nat Commun [11.5] 6: 7690. [Pubmed]