Gerald SPAETH |
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Information |
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Departement of Parasite and Insect vectors | ||
Molecular Parasitology and Signaling | ||
Bordeaux | ||
0000-0002-0256-2029 | ||
This email address is being protected from spambots. You need JavaScript enabled to view it. | ||
https://research.pasteur.fr/en/team/molecular-parasitology-and-signaling/ | ||
Scientific interests and projects |
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The unit ‘Molecular Parasitolgy and Signaling’ conducts multidisciplinary and internationally highly visible research on Leishmania/macrophage interaction and co-evolution. Our program analyses Leishmania and macrophage regulatory pathways implicated in intracellular parasite development and subversion of host cell functions that qualify as novel drug targets. We will pursue three main axes as part of the ParFrap consortium: Axis 1 investigates mechanisms of Leishmania differentiation and evolutionary adaptation by conducting systems level and comparative genomics analyses of hamster-derived parasites and clinical isolates with the aim to identify genetic loci that are linked to Leishmania fitness gain in culture and in infected animals; Axis 2 analyses the signalling role of the Leishmania ecto-kinase CK1.2 and its role in subversion of host cell immune signalling, with the aim to target its exosomal release for anti-leishmanial therapy; Axis 3 studies mechanisms of Leishmania host subversion using immunological, pharmacological and systems-level investigations, with the aims to (i) discover host-directed, anti-leishmanial hits and (ii) study the impact of intracellular Leishmania infection on macrophage epigenetic regulation, phenotype and functions. Together these three axes provide important added value to the main ParaFrap scientific work packages, including WP1 on post genomic data exploration (Axes 1 – 3), WP2 on mechanisms of pathogenesis and anti-parasite immunity (Axes 2 and 3), WP3 on parasite molecular and cellular biology (Axes 1 and 3), and WP4 on development of new intervention strategies against parasitic pathogens (Axes 2 and 3). |
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Top 5 publications of the last 5 years | ||
1. Bussotti G et al. and Späth GF. Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene CNV, Karyotype Instability, and Telomeric Amplification. MBio. 2018 doi: 10.1128/mBio.01399-18 2. Prieto Barja P et al. and Späth GF. Haplotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani. Nature Ecol Evol, 2017. doi: 10.1038/s41559-017-0361-x 3. Drini S et al., and Späth GF. Species- and Strain-Specific Adaptation of the HSP70 Super Family in Pathogenic Trypanosomatids. Genome Biol Evol. 2016. 10.1093/gbe/evw140 4. Cayla M et al. and Späth GF. Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability. PLoS Path. 2014 10.1371/journal.ppat.1004347 5. Dacher M et al. and Späth GF. Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses. Mol Microbiol. 2014 10.1111/mmi.12648 |
Ana Rita Gomes, a CNRS Research Associate at the Laboratory of Pathogens and Host Immunity in Montpellier, and former Postdoctoral fellow of the LabEx ParaFrap, has been awarded the prestigious CNRS Bronze Medal in 2023. This...
. PhD Opportunity, Tours, France Supervision Thesis Supervisor: Sonia LAMANDE; Co-Supervisor: Julie TOTTEY Project: FUNTIONAL CHARACTERISATION OF CYSTEINE CATHEPSINS IN THE APICOMPLEXAN PARASITE CRYPTOSPORIDIUM...
Senior PostDoc position : computational biologist, Paris, France The ParSig team (https://research.pasteur.fr/en/team/molecular-parasitology-and-signaling) at the Institut Pasteur in Paris seeks for a highly...
Researcher in Livestock Immunology for the Study of Animal Trypanosomoses Through a One Health approach, the Intertryp Joint Research Unit (Cirad-IRD) is developing research on interactions between hosts,...
Happy New Year 2024! To kick off this new scientific year, here is the ParaFrap webinar schedule. Since January 2021, ParaFrap has been organizing a series of webinars. This monthly event, held every 2nd Thursday of the month, aims to strengthen...
PostDoc position : functional analysis of P. falciparum early gametocyte proteins, Allschwil, Switzerland The Malaria Gene Regulation Lab of Till Voss is looking for a highly motivated and talented postdoc to...
The team of Dr. Mohamed-Ali Hakimi, in collaboration with Isabelle Coppens (Johns Hopkins University Bloomberg School of Public Health and Malaria Research Institute, Baltimore, MD, USA), has developed a new (epi)genetic method to produce in vitro...
Success for ParaFrap students at MPM2023 Parafrap students won numerous awards at the MPM 2023, Woods Hole USA, 17-21 September 2023. A warm congratulations to all ! Parul Sharma (2nd year PhD under the...
Predoctoral and Postdoctoral positions - Barcelona, Spain Project Leader: Alfred Cortés, PhD - Barcelona Institute for Global Health Hospital Clínic - Universitat de Barcelona Positions: A predoctoral and two...
PhD Position Perpignan, France Project Leader Ronaldo DE CARVALHO AUGUSTO (CPJ, UPVD), principal supervisor (50%) Jérôme BOISSIER (PU, UPVD), PI (50%) Project: Unveiling the Dark Secrets of Roommate Parasites: A Study...
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