![]() |
Gerald SPAETH |
|
Information |
||
![]() |
Departement of Parasite and Insect vectors | |
![]() |
Molecular Parasitology and Signaling | |
![]() |
Bordeaux | |
![]() |
0000-0002-0256-2029 | |
![]() |
Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser. | |
![]() |
https://research.pasteur.fr/en/team/molecular-parasitology-and-signaling/ | |
Scientific interests and projects |
||
The unit ‘Molecular Parasitolgy and Signaling’ conducts multidisciplinary and internationally highly visible research on Leishmania/macrophage interaction and co-evolution. Our program analyses Leishmania and macrophage regulatory pathways implicated in intracellular parasite development and subversion of host cell functions that qualify as novel drug targets. We will pursue three main axes as part of the ParFrap consortium: Axis 1 investigates mechanisms of Leishmania differentiation and evolutionary adaptation by conducting systems level and comparative genomics analyses of hamster-derived parasites and clinical isolates with the aim to identify genetic loci that are linked to Leishmania fitness gain in culture and in infected animals; Axis 2 analyses the signalling role of the Leishmania ecto-kinase CK1.2 and its role in subversion of host cell immune signalling, with the aim to target its exosomal release for anti-leishmanial therapy; Axis 3 studies mechanisms of Leishmania host subversion using immunological, pharmacological and systems-level investigations, with the aims to (i) discover host-directed, anti-leishmanial hits and (ii) study the impact of intracellular Leishmania infection on macrophage epigenetic regulation, phenotype and functions. Together these three axes provide important added value to the main ParaFrap scientific work packages, including WP1 on post genomic data exploration (Axes 1 – 3), WP2 on mechanisms of pathogenesis and anti-parasite immunity (Axes 2 and 3), WP3 on parasite molecular and cellular biology (Axes 1 and 3), and WP4 on development of new intervention strategies against parasitic pathogens (Axes 2 and 3). |
||
Top 5 publications of the last 5 years | ||
1. Bussotti G et al. and Späth GF. Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene CNV, Karyotype Instability, and Telomeric Amplification. MBio. 2018 doi: 10.1128/mBio.01399-18 2. Prieto Barja P et al. and Späth GF. Haplotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani. Nature Ecol Evol, 2017. doi: 10.1038/s41559-017-0361-x 3. Drini S et al., and Späth GF. Species- and Strain-Specific Adaptation of the HSP70 Super Family in Pathogenic Trypanosomatids. Genome Biol Evol. 2016. 10.1093/gbe/evw140 4. Cayla M et al. and Späth GF. Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability. PLoS Path. 2014 10.1371/journal.ppat.1004347 5. Dacher M et al. and Späth GF. Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses. Mol Microbiol. 2014 10.1111/mmi.12648 |
Success for ParaFrap students at MPM2023 Parafrap students won numerous awards at the MPM 2023, Woods Hole USA, 17-21 September 2023. A warm congratulations to all ! Parul Sharma (2nd year PhD under the...
Predoctoral and Postdoctoral positions - Barcelona, Spain Project Leader: Alfred Cortés, PhD - Barcelona Institute for Global Health Hospital Clínic - Universitat de Barcelona Positions: A predoctoral and two...
PhD Position Perpignan, France Project Leader Ronaldo DE CARVALHO AUGUSTO (CPJ, UPVD), principal supervisor (50%) Jérôme BOISSIER (PU, UPVD), PI (50%) Project: Unveiling the Dark Secrets of Roommate Parasites: A Study...
PostDoc position : Saeij Lab, Davis, California, USA The Saeij lab (https://saeijlab.faculty.ucdavis.edu/) at the University of California, Davis, is currently looking for several postdoctoral scholars to work on...
PostDoc position : Identify new repository molecules against Cryptosporidium, Tours, France The lab seeks to hire a highly motivated candidate to work on the identification of new repository molecules against...
Emerging Leader Research Fellow, Oxford Brookes University, UK The Oxford Brookes University offers an opportunity to develop an independent research group in molecular parasitology/protistology through a...
PostDoc position : Gene regulation/ DNA low complexity regions-DNA binding proteins, Montpellier, France The post-doc project aims to investigate the role of Low Complexity Regions in regulation of gene expression in P....
Short-Term Scientific Missions (STSMs) within the OneHealthdrugs (CA21111) network 1st CALL for applications 2023 The 1st STSM Call of the Action CA2111 OneHealthdrugs is launched. Short Term Scientific Mission...
PostDoc position : Cross-talk between stress response and infection in dendritic cells at Institut Pasteur Lille, France We seek to hire a highly motivated candidate to work on the role of the Unfolded Protein...
[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs moléculaires de l'invasion des bradyzoïtes et...
Actualités du LabEx
Autres actualités
Project Manager: Yoann MILLERIOUX
Contact
![]() |
@ParaFrap #ParaFrap |
© 2023. Tous droits réservés by MLCOM
Notre site LabEx ParaFrap utilise des cookies pour réaliser des statistiques de visites, partager des contenus sur les réseaux sociaux et améliorer votre expérience. En refusant les cookies, certains services seront amenés à ne pas fonctionner correctement. Nous conservons votre choix pendant 30 jours. Vous pouvez changer d'avis en cliquant sur le bouton 'Cookies' en bas à gauche de chaque page de notre site. En savoir plus
Ce site utilise des cookies pour assurer son bon fonctionnement et ne peuvent pas être désactivés de nos systèmes. Nous ne les utilisons pas à des fins publicitaires. Si ces cookies sont bloqués, certaines parties du site ne pourront pas fonctionner.
Ce site utilise des cookies de mesure et d’analyse d’audience, tels que Google Analytics et Google Ads, afin d’évaluer et d’améliorer notre site internet.
Ce site utilise des composants tiers, tels que NotAllowedScript6575126ca8f4fReCAPTCHA, Google NotAllowedScript6575126ca8accMaps, MailChimp ou Calameo, qui peuvent déposer des cookies sur votre machine. Si vous décider de bloquer un composant, le contenu ne s’affichera pas
Des plug-ins de réseaux sociaux et de vidéos, qui exploitent des cookies, sont présents sur ce site web. Ils permettent d’améliorer la convivialité et la promotion du site grâce à différentes interactions sociales.
Ce site web utilise un certain nombre de cookies pour gérer, par exemple, les sessions utilisateurs.