Yvon STERKERS |
||
Information |
||
MIVEGEC | ||
Biologie, Génétique et Pathologie des Pathogènes Eucaryotes | ||
Montpellier | ||
0000-0002-5623-5664 | ||
This email address is being protected from spambots. You need JavaScript enabled to view it. | ||
https://mivegec.fr/ | ||
Scientific interests and projects |
||
The team's interest relies in the molecular and cell biology of protozoan parasites, with a focus on Trypanosomatids (Leishmania and Trypanosoma brucei). More precisely, we seek to elucidate the mechanisms of basic biological processes of the parasite cell which are 'divergent' from classical eukaryotic models – and more specifically related to mitosis, e.g. DNA replication, chromosomal segregation, recombination, spindle assembly, cell division … One of the great conceptual achievements of the group over the last 10 years has been the demonstration of a constitutive so-called 'mosaic aneuploidy' in Leishmania, which, even if exaggerated in in vitro conditions (as opposed to the 'real life' of the parasite), questions its astonishing ability to generate and tolerate aneuploidy. This may be related to a greater tolerance to mis-replication or to some degree of 'permissive' segregation – and this is still being elucidated. More on the 'cell biology' side, the team takes interest into microtubular structures and microtubule-associated proteins, which are deeply involved in events such as cell growth and cell division. Present projects focus on the role of post-translational modifications of microtubules and that of kinesins in cell division. For these studies, the group has developed novel molecular tools, in particular the first efficient CRISPR-Cas9 strategy in Leishmania and more recently, has set up an efficient and straightforward approach for inducible knock-outs, opening for the first time the way to the study of essential genes in this parasite. It also takes advantage of the mastering by the team of two demanding techniques, DNA molecular combing and FISH, as well as obviously, more 'classical' approaches such as microscopy and imaging, WGS, ChIP, etc. Collaborations are open about (i) these matters/models with different view angles or technological approaches, or (ii) different models of which the study would benefit from technical approaches not necessarily mastered in the network. |
||
Top 5 publications of the last 5 years |
||
1. Morelle C*, Sterkers Y*°, Crobu L, MBang-Benet DE, Kuk N, Portalès P, Bastien P, Pagès M°, Lachaud L°. The nucleoporin Mlp2 is involved in chromosomal distribution during mitosis in trypanosomatids. Nucleic Acids Res. 2015 Apr 30;43(8):4013-27. *cofirst and °co-corresponding author. doi: 10.1093/nar/gkv056 2. Garcia-Silva MR, Sollelis L, MacPherson CR, Stanojcic S, Kuk N, Crobu L, Bringaud F, Bastien P, Pagès M, Scherf A, Sterkers Y. Identification of the centromeres of Leishmania major: revealing the hidden pieces. EMBO Rep. 2017 Nov;18(11):1968-1977. 10.15252/embr.201744216 3. Vergnes B, Gazanion E, Mariac C, Du Manoir M, Sollelis L, Lopez-Rubio JJ, Sterkers Y, Bañuls AL. A single amino acid substitution (H451Y) in Leishmania calcium-dependent kinase SCAMK confers high tolerance and resistance to antimony. J Antimicrob Chemother. 2019 Nov 1;74(11):3231-3239. doi: 10.1093/jac/dkz334 4. Sollelis L, Ghorbal M, MacPherson CR, Martins RM, Kuk N, Crobu L, Bastien P, Scherf A, Lopez-Rubio JJ, Sterkers Y. First efficient CRISPR-Cas9-mediated genome editing in Leishmania parasites. Cell Microbiol. 2015 Oct;17(10):1405-12. doi: 10.1111/cmi.12456 5. Stanojcic S, Sollelis L, Kuk N, Crobu L, Balard Y, Schwob E, Bastien P, Pagès M, Sterkers Y. Single-molecule analysis of DNA replication reveals novel features in the divergent eukaryotes Leishmania and Trypanosoma brucei versus mammalian cells. Sci Rep. 2016 Mar 15;6:23142. doi: 10.1038/srep23142 |
Postdoctoral position, Institut Pasteur, Paris, France A 24-month post-doctoral position starting on March 1st 2025 and funded by the French National Research Agency (ANR) is available in the Trypanosome...
Postdoctoral positions, LPHI Lab, Montpellier, France Two ERC-funded (JANUS 2024-2029) postdoc positions are open in the lab to study cell cycle regulation in malaria...
Postdoctoral position, Institut Pasteur, Paris, France A postdoc position is available at the Institut Pasteur Paris, in the signalling and host-parasite interactions research group, headed by Dr Najma Rachidi...
ABOUT SPEAKERS PROGRAMME REGISTRATION CONTACT LOCATION About the workshop ParaFrap is organizing the ParaFrap Next Generation in Parasitology...
[Communiqué] As part of the actions of the Health Innovation Plan 2030, the health component of the France 2030 plan, Mohamed-Ali Hakimi is one of the 22 laureates of an Excellence Chair in Biology/Health, supported to conduct high-level research...
The York Biomedical Research Institute (YBRI) are hosting an online live seminar on Friday 24th May 1-2pm BST as part of their biomedical science seminar series. You are all welcome to attend - registration is required via the...
[Communiqué] Congratulations to Arthur Talman, IRD Research Leader in the MIVEGEC laboratory (Montpellier), who has been awarded an Advanced Grant from the European Research Council (ERC) for the project "TROJAN - Molecular mimicry and immune...
Ana Rita Gomes, a CNRS Research Associate at the Laboratory of Pathogens and Host Immunity in Montpellier, and former Postdoctoral fellow of the LabEx ParaFrap, has been awarded the prestigious CNRS Bronze Medal in 2023. This...
Happy New Year 2024! To kick off this new scientific year, here is the ParaFrap webinar schedule. Since January 2021, ParaFrap has been organizing a series of webinars. This monthly event, held every 2nd Thursday of the month, aims to strengthen...
The team of Dr. Mohamed-Ali Hakimi, in collaboration with Isabelle Coppens (Johns Hopkins University Bloomberg School of Public Health and Malaria Research Institute, Baltimore, MD, USA), has developed a new (epi)genetic method to produce in vitro...
© 2023. All rights reserved MLCOM
Notre site LabEx ParaFrap utilise des cookies pour réaliser des statistiques de visites, partager des contenus sur les réseaux sociaux et améliorer votre expérience. En refusant les cookies, certains services seront amenés à ne pas fonctionner correctement. Nous conservons votre choix pendant 30 jours. Vous pouvez changer d'avis en cliquant sur le bouton 'Cookies' en bas à gauche de chaque page de notre site. En savoir plus
Ce site utilise des cookies pour assurer son bon fonctionnement et ne peuvent pas être désactivés de nos systèmes. Nous ne les utilisons pas à des fins publicitaires. Si ces cookies sont bloqués, certaines parties du site ne pourront pas fonctionner.
Ce site utilise des cookies de mesure et d’analyse d’audience, tels que Google Analytics et Google Ads, afin d’évaluer et d’améliorer notre site internet.
Ce site utilise des composants tiers, tels que NotAllowedScript672cb38e09b57ReCAPTCHA, Google NotAllowedScript672cb38e095a7Maps, MailChimp ou Calameo, qui peuvent déposer des cookies sur votre machine. Si vous décider de bloquer un composant, le contenu ne s’affichera pas
Des plug-ins de réseaux sociaux et de vidéos, qui exploitent des cookies, sont présents sur ce site web. Ils permettent d’améliorer la convivialité et la promotion du site grâce à différentes interactions sociales.
Ce site web utilise un certain nombre de cookies pour gérer, par exemple, les sessions utilisateurs.