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Sylviane PIED |
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Information |
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Centre d'Infection et d'Immunité de Lille-CIIL-CNRS UMR 8204-INSERM 1019-Université de Lille-Institut Pasteur de Lille | |
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Tropical Biomes and Immunopathophysiology-TBIP | |
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Lille | |
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0000-0003-0642-1423 | |
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This email address is being protected from spambots. You need JavaScript enabled to view it. | |
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https://www.ciil.fr/teams/tropical-biome-immuno-pathophysiology | |
Scientific interests and projects |
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TBIP scientific activities focus on (co)transmitted protozoan parasitic diseases in French Guiana Amazonia such as Malaria, Leishmaniasis and Toxoplasmosis. We aim at to elucidating common and divergent immune mechanisms associated with severe disease or protection induced by these protozoan parasite infections and their modulation by environmental parameters on disease outcome in the French Guiana Amazonian ecosystem, a region with abundant biodiversity and a multicultural, multiethnic population, in a “one health” strategy by capitalizing on the strength and multidisciplinary character of the new team consisting of clinicians working on the field, experts in molecular parasitology and epidemiology, and immunologists. The open questions this project will answer through a multidiciplinary integrated workprogram combining conceptual and methodological approaches with experimental and clinical studies are the following: what are the mechanisms of natural protective (or anti-disease) immunity that control the parasite and, limit collateral damage to the host? How are these processes impacted by internal (host) and external (environmental) factors? Does and how the parasite genotype influence the protective response? How do multiple co-transmitted parasites interact to give rise to protection or pathogenesis? The French Amazonian region offers the possibility to study these different parameters in an integrated manner in exposed individuals. The project will also function within the framework of the LabEx CEBA: “Center for the study of biodiversity in Amazonia” and in the CNRS “Observatoire Homme-Milieux” OMH Oyapock station (http://ohmoyapock. in2p3.fr). Our project fulfills the objective of the WP2 of the LabEx aiming at UNDERSTANDING PROTECTIVE IMMUNITY AND IMPROVING VACCINE DEVELOPMENT and particularly the specific aims 1) map new modulatory molecules and biomarkers underlying parasite infections and (ii) use immunomics to guide the search for more efficacious vaccines. |
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Top 5 publications of the last 5 years |
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1. Keswani T, Roland J, Herbert F, Delcroix-Genete D, Bauderlique-Le Roy H, Gaayeb L, Cazenave PA, Pied S. (2019) Expression of CD300lf by microglia contributes to resistance to cerebral malaria by impeding the neuroinflammation. Genes Immun. doi: 10.1038/s41435-019-0085-9. 2. Shrivastava SK, Dalko E, Delcroix-Genete D, Herbert F, Cazenave PA, Pied S. (2017) Uptake of parasite-derived vesicles by astrocytes and microglial phagocytosis of infected erythrocytes may drive neuroinflammation in cerebral malaria. Glia. 65(1):75-92. doi: 10.1002/glia.23075. 3. Dalko E, Genete D, Auger F, Dovergne C, Lambert C, Herbert F, Cazenave PA, Roland J, Pied S. (2016) Heme dampens T-cell sequestration by modulating glial cell responses during rodent cerebral malaria. Brain Behav Immun. 58:280-290. doi: 10.1016/j.bbi.2016.07.157. 4. Herbert F, Tchitchek N, Bansal D, Jacques J, Pathak S, Bécavin C, Fesel C, Dalko E, Cazenave PA, Preda C, Ravindran B, Sharma S, Das B, Pied S. (2015) Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17pathway in acute renal failure associated to Plasmodium falciparum malaria. J Transl Med. 13:369. doi: 10.1186/s12967-015-0731-6. 5. Blanc AL, Keswani T, Gorgette O, Bandeira A, Malissen B, Cazenave PA, Pied S. (2015) Suppression of CD4+ Effector Responses by Naturally Occurring CD4+ CD25+ Foxp3+ Regulatory T Cells Contributes to Experimental Cerebral Malaria. Infect Immun. 84(1):329-38. doi: 10.1128/IAI.00717-15. |
[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs moléculaires de l'invasion des bradyzoïtes et...
LabEx ParaFrap wishes you happiness, health, science and success for 2023. First news from the network this year: the ParaFrap webinars will be back in 2023, as in previous years, every second Thursday of the month at 3pm. If you are not yet on the...
PostDoc position in Biological Sciences / Biochemistry: Mode of action of antimalarial benzylmenadiones at IBMC, Strasbourg, France A renewable 1-year postdoctoral position is open at IBMC (Inserm/CNRS/University...
[Communiqué] Gerald Spaeth, head of the "Molecular Parasitology and Signalling" unit at the Institut Pasteur Paris, has been awarded a Synergy grant from the European Research Council (ERC) for the project "DECOLeishRN - Decoding...
PostDoc position studying host-pathogen interactions at Institut Pasteur, Paris, France A postdoc position is available at the Institut Pasteur in the signalling and host-parasite interactions group, headed by Najma Rachidi, to investigate the...
[Communiqué] The team of Dr Chetan Chitnis from the Institut Pasteur, a partner in LabEx ParaFrap, has studied the blood stage of the Plasmodium falciparum parasite, which causes the most severe and deadly form of malaria, and discovered a...
PhD Position in Single Particle Imaging of P. falciparum Knobs Project Leader Prof. Dr. Michael Lanzer (Heidelberg University Hospital, Centre for Infectious Diseases, Parasitology Unit, INF 324, 69120 Heidelberg, Germany)...
PostDoc position in Biological Chemistry/Biochemistry/Proteomics at University of Strasbourg, France A renewable 6 month post-doctoral position is open at the ECPM (University of Strasbourg) to use activity-based protein...
Dear colleagues,The EMBO Workshop "New frontiers in host-parasite interactions, from cell to organism", supported by...
Position: External Recruitment Competition (permanent position) - Assistant Engineer in biology, life and earth sciences Details:Study of the cytoskeleton in Trypanosoma brucei and Toxoplasma gondii...
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