Image

French Alliance for Parasitology and Health Care

 

  Philippe Bastin

 

Philippe BASTIN

Information

microscope Trypanosome Cell Biology Unit 
location Paris, Institut Pasteur
orcid 0000-0002-3042-8679 
email This email address is being protected from spambots. You need JavaScript enabled to view it.
website https://research.pasteur.fr/en/team/trypanosome-cell-biology/
twitter @BastinLab_Paris 

Scientific interests and projects

The Trypanosome Cell Biology Unit fits perfectly with the 4 major scientific topics highlighted by the ParaFrap consortium:

• Post-genomic data exploration: The unit is studying the function of various genes in trypanosomes, especially at the level of the cytoskeleton, using a collection of tools such as inducible RNAi, double knockout, gene replacement or Cas9/Cas13 approaches. This is done at the level of parasites in culture but also during infection in tsetse flies or in mice.

• Mechanisms of pathogenesis: Thanks to its own tsetse fly breeding colony, the unit can ask questions through the full life cycle of African trypanosomes and importantly it can study the infection via the natural route that is the bite of the tsetse fly.

• Parasite molecular and cellular biology: The unit is well known for cell biology, especially in the context of cell movement, protein trafficking and organelle function, once again in in vitro and in vivo contexts.

• Towards new intervention strategies against parasitic pathogens: The work carried out in the field in collaboration with the IRD and partners in Africa has significant potential for the diagnosis of gambiense HAT and could change the way both patient treatment and follow-up is carried out. It could be very significant for the WHO programme of elimination of the disease

Top 5 publications of the last 5 years

1. Bertiaux, E., Morga, B., Blisnick, T., Rotureau, B., and Bastin, P. (2018). A Grow-and-Lock Model for the Control of Flagellum Length in Trypanosomes. Curr Biol 28, 3802-3814 e3803. doi: 10.1016/j.cub.2018.10.031

2. Bonnefoy, S., Watson, C.M., Kernohan, K.D., Lemos, M., Hutchinson, S., Poulter, J.A., Crinnion, L.A., Berry, I., Simmonds, J., Vasudevan, P., O'Callaghan, C., Hirst, R.A., Rutman, A., Huang, L., Hartley, T., Grynspan, D., Moya, E., Li, C., Carr, I.M., Bonthron, D.T., Leroux, M., Care4Rare Canada, C., Boycott, K.M., Bastin, P., and Sheridan, E.G. (2018). . Am J Hum Genet 103, 727-739. doi: 10.1016/j.ajhg.2018.10.003

3. Bertiaux, E., Mallet, A., Fort, C., Blisnick, T., Bonnefoy, S., Jung, J., Lemos, M., Marco, S., Vaughan, S., Trepout, S., Tinevez, J.Y., and Bastin, P. (2018). Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum. J Cell Biol 217, 4284-4297. doi: 10.1083/jcb.201805030

4. Calvo-Alvarez, E., Cren-Travaille, C., Crouzols, A., and Rotureau, B. (2018). A new chimeric triple reporter fusion protein as a tool for in vitro and in vivo multimodal imaging to monitor the development of African trypanosomes and Leishmania parasites. Infect Genet Evol 63, 391-403. doi: 10.1016/j.meegid.2018.01.011

5. Capewell, P., Cren-Travaille, C., Marchesi, F., Johnston, P., Clucas, C., Benson, R.A., Gorman, T.A., Calvo-Alvarez, E., Crouzols, A., Jouvion, G., Jamonneau, V., Weir, W., Stevenson, M.L., O'Neill, K., Cooper, A., Swar, N.K., Bucheton, B., Ngoyi, D.M., Garside, P., Rotureau, B., and MacLeod, A. (2016). The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes. Elife 5:e17716. doi: 10.7554/eLife.17716

>

TRAINING PROGRAM

International PhD Program

NEWS

LabEx News
Other News

 

CONTACT

Project Manager: Yoann MILLERIOUX
Contact

Twitter Social Icon Rounded Square Color @ParaFrap #ParaFrap

Cookies settings

×

Functional Cookies

Ce site utilise des cookies pour assurer son bon fonctionnement et ne peuvent pas être désactivés de nos systèmes. Nous ne les utilisons pas à des fins publicitaires. Si ces cookies sont bloqués, certaines parties du site ne pourront pas fonctionner.

Measure of audience

Ce site utilise des cookies de mesure et d’analyse d’audience, tels que Google Analytics et Google Ads, afin d’évaluer et d’améliorer notre site internet.

Interactive Content

Ce site utilise des composants tiers, tels que NotAllowedScript66744c542f0c0ReCAPTCHA, Google NotAllowedScript66744c542ec75Maps, MailChimp ou Calameo, qui peuvent déposer des cookies sur votre machine. Si vous décider de bloquer un composant, le contenu ne s’affichera pas

Social Networks / Videos

Des plug-ins de réseaux sociaux et de vidéos, qui exploitent des cookies, sont présents sur ce site web. Ils permettent d’améliorer la convivialité et la promotion du site grâce à différentes interactions sociales.

Session

Please login to see yours activities!

Other cookies

Ce site web utilise un certain nombre de cookies pour gérer, par exemple, les sessions utilisateurs.