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Maryse LEBRUN |
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Information |
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Laboratory of Pathogen Host Interactions | |
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Cell biology of apicomplexan parasites | |
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Montpellier | |
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0000-0002-0962-0156 | |
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This email address is being protected from spambots. You need JavaScript enabled to view it. | |
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https://cutt.ly/sw2i2ZC | |
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@Lebrun43782700 | |
Scientific interests and projects |
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We are interested in the cellular and molecular mechanisms that enable apicomplexan parasites to infect and develop inside their host. The phylum Apicomplexa comprises single-celled eukaryotic parasites. They are important pathogens of humans and domestic animals. It includes Plasmodium spp. the causative agent of malaria, responsible for almost half million human deaths per year. It also includes Toxoplasma, a prominent cause of human congenital infections, and Cryptosporidium, a leading cause of severe diarrhea and mortality in infants. No vaccine currently exists against these parasites. The objectives of our team are to decipher cellular and molecular features related to two essential parasitic functions: host cell invasion and intracellular replication, with the aim of identifying novel therapeutic strategies. Our research is mainly focused on T. gondii, which is a relevant model for many features conserved throughout the phylum. We then extend our important discoveries to the malaria parasite. We use a broad array of cell biological and biochemical approaches, as well as cutting-edge molecular genetics and genome editing. The M. Lebrun group explores i) the structure/function of proteins constituting the moving junction, a key structure formed during invasion of the host cell, ii) the mechanisms that trigger rhoptry exocytosis upon binding of the parasite to the host cell, iii) the fusion machinery of the rhoptry with the parasite plasma membrane, and iv) how rhoptry content is introduced in the host. The group of S. Besteiro focuses on the contribution of an endosymbiotic organelle to the metabolism and survival of T. gondii in the context of both the acute and chronic phases of toxoplasmosis. The group of M. Lamarque is interested in the functional characterization of selected P. falciparum phosphatases related to the invasion and egress mechanisms. |
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Top 5 publications of the last 5 years |
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1. Suarez C, Lentini G, Ramaswamy R, Maynadier M, Aquilini E, Berry-Sterkers L, Cipriano M, Chen AL, Bradley P, Striepen B, Boulanger MJ, Lebrun M. A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites. (2019). Nature Communications. 10(1):4041. doi: 10.1038/s41467-019-11979-z 2. Guérin A, Corrales RM, Parker ML, Lamarque MH, Jacot D, El Hajj H, Soldati-Favre D, Boulanger MJ, Lebrun M. Efficient invasion by Toxoplasma depends on the subversion of host protein networks. Nature Microbiology, (2017) Oct;2(10):1358-1366. doi: 10.1038/s41564-017-0018-1 3. Nguyen HM, El Hajj H, El Hajj R, Tawil N, Berry L, Lebrun M, Bordat Y, Besteiro S. Toxoplasma gondii autophagy-related protein ATG9 is crucial for the survival of parasites in their host. Cellular Microbiology, (2017) Jun (19) 6. doi: 10.1111/cmi.12712 4. Parker ML, Penarete-Vargas DM, Hamilton PT, Guérin A, Dubey JP, Perlman SJ, Spano F, Lebrun M *, Boulanger MJ*. Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA-RON2 pair. PNAS, (2016) Jan 12;113(2):398-403. *equal contribution. doi: 10.1073/pnas.1515898113 5. Lévêque MF, Berry L, Cipriano MJ, Nguyen HM, Striepen B, Besteiro S. Autophagy- Related Protein ATG8 Has a Noncanonical Function for Apicoplast Inheritance in Toxoplasma gondii. MBio. (2015) Oct 27;6(6):e01446-15. 10.1128/mBio.01446-15 |
Success for ParaFrap students at MPM2023 Parafrap students won numerous awards at the MPM 2023, Woods Hole USA, 17-21 September 2023. A warm congratulations to all ! Parul Sharma (2nd year PhD under the...
Predoctoral and Postdoctoral positions - Barcelona, Spain Project Leader: Alfred Cortés, PhD - Barcelona Institute for Global Health Hospital Clínic - Universitat de Barcelona Positions: A predoctoral and two...
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Emerging Leader Research Fellow, Oxford Brookes University, UK The Oxford Brookes University offers an opportunity to develop an independent research group in molecular parasitology/protistology through a...
PostDoc position : Gene regulation/ DNA low complexity regions-DNA binding proteins, Montpellier, France The post-doc project aims to investigate the role of Low Complexity Regions in regulation of gene expression in P....
Short-Term Scientific Missions (STSMs) within the OneHealthdrugs (CA21111) network 1st CALL for applications 2023 The 1st STSM Call of the Action CA2111 OneHealthdrugs is launched. Short Term Scientific Mission...
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[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs moléculaires de l'invasion des bradyzoïtes et...
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