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French Parasitology Alliance For Health Care


  JJ Lopez Rubio



microscope Laboratory of Pathogen-Host Interactions (LPHI), UMR5235 
team Plasmodium DNA biology 
location Montpellier
orcid 0000-0002-0555-1122 
email This email address is being protected from spambots. You need JavaScript enabled to view it.

Scientific interests and projects

Our team uses cutting edge technologies to understand DNA biology in Plasmodium falciparum, a unicellular eukaryotic parasite that causes the most severe form of malaria in humans. Given the tight regulation of gene expression in malaria parasites, the apparent paucity of transcription-associated factors is surprising and points to existence of divergent regulatory pathways. Our projects investigate two emerging mechanisms for gene regulation, non coding RNA and G4-quadruplex DNA secondary structures. Such divergent regulatory mechanisms present ideal drug targets that may be explored for new antimalarial strategies.

Top 5 publications of the last 5 years

1. Lee MCS, Lindner SE, Lopez-Rubio JJ, Llinas M. Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium. Brief Funct Genomics. 2019 Jul 29. pii: elz012. doi: 10.1093/bfgp/elz012

2. Belmonte-Reche E, Martínez-García M, Guédin A, Zuffo M, Arévalo-Ruiz M, Doria F, Campos-Salinas J, Maynadier M, López-Rubio JJ, Freccero M, Mergny JL, Pérez-Victoria JM, Morales JC. G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents. J Med Chem. 2018 Feb 8;61(3):1231-1240. doi: 10.1021/acs.jmedchem.7b01672

3. Sollelis L, Ghorbal M, MacPherson CR, Martins RM, Kuk N, Crobu L, Bastien P, Scherf A, Lopez-Rubio JJ, Sterkers Y. First efficient CRISPR-Cas9-mediated genome editing in Leishmania parasites. Cell Microbiol. 2015 Oct;17(10):1405-12. doi: 10.1111/cmi.12456

4. Mbengue A, Bhattacharjee S, Pandharkar T, Liu H, Estiu G, Stahelin RV, Rizk SS, Njimoh DL, Ryan Y, Chotivanich K, Nguon C, Ghorbal M, Lopez-Rubio JJ, Pfrender M, Emrich S, Mohandas N, Dondorp AM, Wiest O, Haldar K. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature. 2015 Apr 30;520(7549):683-7. doi: 10.1038/nature14412

5. Ghorbal M, Gorman M, Macpherson CR, Martins RM, Scherf A, Lopez-Rubio JJ. Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPRCas9 system. Nat Biotechnol. 2014 Aug;32(8):819-21. doi: 10.1038/nbt.2925