-
ABOUT
- Who are we
- Objectives of the LabEx
- Laboratories and teams
- Directory Board
- Industrial collaborators
- Institutional and Financial Supports
- GOVERNANCE
- Organigram
- Steering committee
- Executive Committee
- External Scientific Advisory Board
- Institutional Board
- TRAINING
- CONFERENCES
- PROJECTS
- Post genomic data exploration
- Mechanisms of pathogenesis
- Parasite molecular and cellular biology
- Towards new intervention strategies against parasitic pathogens
- Plateforms
- VALORIZATION
-
ABOUT
- Who are we
- Objectives of the LabEx
- Laboratories and teams
- Directory Board
- Industrial collaborators
- Institutional and Financial Supports
- GOVERNANCE
- Organigram
- Steering committee
- Executive Committee
- External Scientific Advisory Board
- Institutional Board
- TRAINING
Jose-Juan
LOPEZ-RUBIOInformation
Laboratory of Pathogen-Host Interactions (LPHI), UMR5235 
Plasmodium DNA biology 
Montpellier 
0000-0002-0555-1122 
This email address is being protected from spambots. You need JavaScript enabled to view it. 
https://lphi.umontpellier.fr/en/lphi-teams/plasmodium-genome-plasticity Scientific interests and projects
Our team uses cutting edge technologies to understand DNA biology in Plasmodium falciparum, a unicellular eukaryotic parasite that causes the most severe form of malaria in humans. Given the tight regulation of gene expression in malaria parasites, the apparent paucity of transcription-associated factors is surprising and points to existence of divergent regulatory pathways. Our projects investigate two emerging mechanisms for gene regulation, non coding RNA and G4-quadruplex DNA secondary structures. Such divergent regulatory mechanisms present ideal drug targets that may be explored for new antimalarial strategies.
Top 5 publications of the last 5 years
1. Lee MCS, Lindner SE, Lopez-Rubio JJ, Llinas M. Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium. Brief Funct Genomics. 2019 Jul 29. pii: elz012. doi: 10.1093/bfgp/elz012
2. Belmonte-Reche E, Martínez-García M, Guédin A, Zuffo M, Arévalo-Ruiz M, Doria F, Campos-Salinas J, Maynadier M, López-Rubio JJ, Freccero M, Mergny JL, Pérez-Victoria JM, Morales JC. G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents. J Med Chem. 2018 Feb 8;61(3):1231-1240. doi: 10.1021/acs.jmedchem.7b01672
3. Sollelis L, Ghorbal M, MacPherson CR, Martins RM, Kuk N, Crobu L, Bastien P, Scherf A, Lopez-Rubio JJ, Sterkers Y. First efficient CRISPR-Cas9-mediated genome editing in Leishmania parasites. Cell Microbiol. 2015 Oct;17(10):1405-12. doi: 10.1111/cmi.12456
4. Mbengue A, Bhattacharjee S, Pandharkar T, Liu H, Estiu G, Stahelin RV, Rizk SS, Njimoh DL, Ryan Y, Chotivanich K, Nguon C, Ghorbal M, Lopez-Rubio JJ, Pfrender M, Emrich S, Mohandas N, Dondorp AM, Wiest O, Haldar K. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature. 2015 Apr 30;520(7549):683-7. doi: 10.1038/nature14412
5. Ghorbal M, Gorman M, Macpherson CR, Martins RM, Scherf A, Lopez-Rubio JJ. Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPRCas9 system. Nat Biotechnol. 2014 Aug;32(8):819-21. doi: 10.1038/nbt.2925
Friday, 27 January 2023Nouvelles données sur l'invasion de Toxoplasma gondii
[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs moléculaires de l'invasion des bradyzoïtes et...
Tuesday, 03 January 2023Happy Birthday 2023
LabEx ParaFrap wishes you happiness, health, science and success for 2023. First news from the network this year: the ParaFrap webinars will be back in 2023, as in previous years, every second Thursday of the month at 3pm. If you are not yet on the...
Friday, 16 December 2022PostDoc l Biological Sciences l Strasbourg
PostDoc position in Biological Sciences / Biochemistry: Mode of action of antimalarial benzylmenadiones at IBMC, Strasbourg, France A renewable 1-year postdoctoral position is open at IBMC (Inserm/CNRS/University...
Monday, 14 November 2022Gerald Spaeth received a ERC Synergy grant
[Communiqué] Gerald Spaeth, head of the "Molecular Parasitology and Signalling" unit at the Institut Pasteur Paris, has been awarded a Synergy grant from the European Research Council (ERC) for the project "DECOLeishRN - Decoding...
Monday, 10 October 2022PostDoc l Molecular Parasitology l Paris
PostDoc position studying host-pathogen interactions at Institut Pasteur, Paris, France A postdoc position is available at the Institut Pasteur in the signalling and host-parasite interactions group, headed by Najma Rachidi, to investigate the...
Friday, 17 June 2022Une nouvelle cible médicamenteuse contre le paludisme
[Communiqué] The team of Dr Chetan Chitnis from the Institut Pasteur, a partner in LabEx ParaFrap, has studied the blood stage of the Plasmodium falciparum parasite, which causes the most severe and deadly form of malaria, and discovered a...
Friday, 03 June 2022PhD Offer l Malaria l Heidelberg
PhD Position in Single Particle Imaging of P. falciparum Knobs Project Leader Prof. Dr. Michael Lanzer (Heidelberg University Hospital, Centre for Infectious Diseases, Parasitology Unit, INF 324, 69120 Heidelberg, Germany)...
Monday, 11 April 2022PostDoc l Biological Chemistry l Strasbourg
PostDoc position in Biological Chemistry/Biochemistry/Proteomics at University of Strasbourg, France A renewable 6 month post-doctoral position is open at the ECPM (University of Strasbourg) to use activity-based protein...
Friday, 08 April 2022EMBO Workshop Host Parasite
Dear colleagues,The EMBO Workshop "New frontiers in host-parasite interactions, from cell to organism", supported by...
Friday, 01 April 2022Assistant Engineer in Biology ⎜Bordeaux
Position: External Recruitment Competition (permanent position) - Assistant Engineer in biology, life and earth sciences Details:Study of the cytoskeleton in Trypanosoma brucei and Toxoplasma gondii...
TRAINING PROGRAM
Programme Doctoral InternationalProgramme Post-doctoralNEWS
© 2023. All rights reserved MLCOM
Notre site LabEx ParaFrap utilise des cookies pour réaliser des statistiques de visites, partager des contenus sur les réseaux sociaux et améliorer votre expérience. En refusant les cookies, certains services seront amenés à ne pas fonctionner correctement. Nous conservons votre choix pendant 30 jours. Vous pouvez changer d'avis en cliquant sur le bouton 'Cookies' en bas à gauche de chaque page de notre site. En savoir plus
Cookies settings
×Functional Cookies
Ce site utilise des cookies pour assurer son bon fonctionnement et ne peuvent pas être désactivés de nos systèmes. Nous ne les utilisons pas à des fins publicitaires. Si ces cookies sont bloqués, certaines parties du site ne pourront pas fonctionner.
Measure of audience
Ce site utilise des cookies de mesure et d’analyse d’audience, tels que Google Analytics et Google Ads, afin d’évaluer et d’améliorer notre site internet.
- Google Analytics
- Google Ads
Interactive Content
Ce site utilise des composants tiers, tels que NotAllowedScript641a7278cbabdReCAPTCHA, Google NotAllowedScript641a7278cb62dMaps, MailChimp ou Calameo, qui peuvent déposer des cookies sur votre machine. Si vous décider de bloquer un composant, le contenu ne s’affichera pas
- Google Maps
Pour en savoir plus, cliquez sur le lien.
See the official site - Calameo
Pour en savoir plus, cliquez sur le lien.
See the official site - reCaptcha V2
Pour en savoir plus, cliquez sur le lien.
See the official site - reCaptcha V3
Pour en savoir plus, cliquez sur le lien.
See the official site
Social Networks / Videos
Des plug-ins de réseaux sociaux et de vidéos, qui exploitent des cookies, sont présents sur ce site web. Ils permettent d’améliorer la convivialité et la promotion du site grâce à différentes interactions sociales.
- Twitter
Pour en savoir plus, cliquez sur le lien.
See the official site
Session
Please login to see yours activities!Other cookies
Ce site web utilise un certain nombre de cookies pour gérer, par exemple, les sessions utilisateurs.
