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ABOUT
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- Post genomic data exploration
- Mechanisms of pathogenesis
- Parasite molecular and cellular biology
- Towards new intervention strategies against parasitic pathogens
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- VALORIZATION
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ABOUT
- Who are we
- Objectives of the LabEx
- Laboratories and teams
- Directory Board
- Industrial collaborators
- Institutional and Financial Supports
- GOVERNANCE
Jose-Juan
LOPEZ-RUBIOInformation
Laboratory of Pathogen-Host Interactions (LPHI), UMR5235 
Plasmodium DNA biology 
Montpellier 
0000-0002-0555-1122 
This email address is being protected from spambots. You need JavaScript enabled to view it. 
https://lphi.umontpellier.fr/en/lphi-teams/plasmodium-genome-plasticity Scientific interests and projects
Our team uses cutting edge technologies to understand DNA biology in Plasmodium falciparum, a unicellular eukaryotic parasite that causes the most severe form of malaria in humans. Given the tight regulation of gene expression in malaria parasites, the apparent paucity of transcription-associated factors is surprising and points to existence of divergent regulatory pathways. Our projects investigate two emerging mechanisms for gene regulation, non coding RNA and G4-quadruplex DNA secondary structures. Such divergent regulatory mechanisms present ideal drug targets that may be explored for new antimalarial strategies.
Top 5 publications of the last 5 years
1. Lee MCS, Lindner SE, Lopez-Rubio JJ, Llinas M. Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium. Brief Funct Genomics. 2019 Jul 29. pii: elz012. doi: 10.1093/bfgp/elz012
2. Belmonte-Reche E, Martínez-García M, Guédin A, Zuffo M, Arévalo-Ruiz M, Doria F, Campos-Salinas J, Maynadier M, López-Rubio JJ, Freccero M, Mergny JL, Pérez-Victoria JM, Morales JC. G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents. J Med Chem. 2018 Feb 8;61(3):1231-1240. doi: 10.1021/acs.jmedchem.7b01672
3. Sollelis L, Ghorbal M, MacPherson CR, Martins RM, Kuk N, Crobu L, Bastien P, Scherf A, Lopez-Rubio JJ, Sterkers Y. First efficient CRISPR-Cas9-mediated genome editing in Leishmania parasites. Cell Microbiol. 2015 Oct;17(10):1405-12. doi: 10.1111/cmi.12456
4. Mbengue A, Bhattacharjee S, Pandharkar T, Liu H, Estiu G, Stahelin RV, Rizk SS, Njimoh DL, Ryan Y, Chotivanich K, Nguon C, Ghorbal M, Lopez-Rubio JJ, Pfrender M, Emrich S, Mohandas N, Dondorp AM, Wiest O, Haldar K. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature. 2015 Apr 30;520(7549):683-7. doi: 10.1038/nature14412
5. Ghorbal M, Gorman M, Macpherson CR, Martins RM, Scherf A, Lopez-Rubio JJ. Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPRCas9 system. Nat Biotechnol. 2014 Aug;32(8):819-21. doi: 10.1038/nbt.2925
Tuesday, 11 March 2025Associate professor l Toxoplama l Bordeaux, France
Associate Professor : Animal Biology and Parasitology – Host-Pathogen Interactions, Bordeaux, France Teaching Profile The candidate will teach in animal biology, especially in metazoan diversity, phylogeny,...
Wednesday, 26 February 2025EMBO Workshop Host Parasite 2025
The EMBO Workshop "Host-parasite relationship: from mechanisms to control strategies", supported by ParaFrap, will take place from...
Wednesday, 05 February 2025ParaFrap Webinar - Gretchen DIFFENDALL
ParaFrap Webinar Thursday, February 13, 2025 at 15:00 (CET) Gretchen...
Tuesday, 14 January 2025PostDoc x2 l Trypanosoma l Lisbon, PT
Two PostDoc positions on Trypanosoma brucei and its interactions with blood vessels, Lisbon, Portugal A collaborative project in the Lisbon area, Portugal, to explore groundbreaking interactions between...
Thursday, 24 October 2024PostDoc l Trypanosoma l Paris, FR
Postdoctoral position, Institut Pasteur, Paris, France A 24-month post-doctoral position starting on March 1st 2025 and funded by the French National Research Agency (ANR) is available in the Trypanosome...
Monday, 21 October 2024PostDoc x2 l Malaria l Montpellier, FR
Postdoctoral positions, LPHI Lab, Montpellier, France Two ERC-funded (JANUS 2024-2029) postdoc positions are open in the lab to study cell cycle regulation in malaria...
Tuesday, 01 October 2024PostDoc l Leishmania l Paris, FR
Postdoctoral position, Institut Pasteur, Paris, France A postdoc position is available at the Institut Pasteur Paris, in the signalling and host-parasite interactions research group, headed by Dr Najma Rachidi...
Monday, 01 July 2024Next Generation In Parasitology - Workshop
ABOUT SPEAKERS PROGRAMME REGISTRATION CONTACT LOCATION About the workshop ParaFrap is organizing the ParaFrap Next Generation in Parasitology...
Monday, 29 April 2024MA. Hakimi, laureate of the Excellence Chair in Biology/Health France 2030
[Communiqué] As part of the actions of the Health Innovation Plan 2030, the health component of the France 2030 plan, Mohamed-Ali Hakimi is one of the 22 laureates of an Excellence Chair in Biology/Health, supported to conduct high-level research...
Tuesday, 16 April 2024Seminar - Boris Striepen - May 24
The York Biomedical Research Institute (YBRI) are hosting an online live seminar on Friday 24th May 1-2pm BST as part of their biomedical science seminar series. You are all welcome to attend - registration is required via the...
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