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ABOUT
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- Objectives of the LabEx
- Laboratories and teams
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- Organigram
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- Post genomic data exploration
- Mechanisms of pathogenesis
- Parasite molecular and cellular biology
- Towards new intervention strategies against parasitic pathogens
- Plateforms
- VALORIZATION
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ABOUT
- Who are we
- Objectives of the LabEx
- Laboratories and teams
- Directory Board
- Industrial collaborators
- Institutional and Financial Supports
- GOVERNANCE
Jose-Juan
LOPEZ-RUBIOInformation
Laboratory of Pathogen-Host Interactions (LPHI), UMR5235 
Plasmodium DNA biology 
Montpellier 
0000-0002-0555-1122 
This email address is being protected from spambots. You need JavaScript enabled to view it. 
https://lphi.umontpellier.fr/en/lphi-teams/plasmodium-genome-plasticity Scientific interests and projects
Our team uses cutting edge technologies to understand DNA biology in Plasmodium falciparum, a unicellular eukaryotic parasite that causes the most severe form of malaria in humans. Given the tight regulation of gene expression in malaria parasites, the apparent paucity of transcription-associated factors is surprising and points to existence of divergent regulatory pathways. Our projects investigate two emerging mechanisms for gene regulation, non coding RNA and G4-quadruplex DNA secondary structures. Such divergent regulatory mechanisms present ideal drug targets that may be explored for new antimalarial strategies.
Top 5 publications of the last 5 years
1. Lee MCS, Lindner SE, Lopez-Rubio JJ, Llinas M. Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium. Brief Funct Genomics. 2019 Jul 29. pii: elz012. doi: 10.1093/bfgp/elz012
2. Belmonte-Reche E, Martínez-García M, Guédin A, Zuffo M, Arévalo-Ruiz M, Doria F, Campos-Salinas J, Maynadier M, López-Rubio JJ, Freccero M, Mergny JL, Pérez-Victoria JM, Morales JC. G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents. J Med Chem. 2018 Feb 8;61(3):1231-1240. doi: 10.1021/acs.jmedchem.7b01672
3. Sollelis L, Ghorbal M, MacPherson CR, Martins RM, Kuk N, Crobu L, Bastien P, Scherf A, Lopez-Rubio JJ, Sterkers Y. First efficient CRISPR-Cas9-mediated genome editing in Leishmania parasites. Cell Microbiol. 2015 Oct;17(10):1405-12. doi: 10.1111/cmi.12456
4. Mbengue A, Bhattacharjee S, Pandharkar T, Liu H, Estiu G, Stahelin RV, Rizk SS, Njimoh DL, Ryan Y, Chotivanich K, Nguon C, Ghorbal M, Lopez-Rubio JJ, Pfrender M, Emrich S, Mohandas N, Dondorp AM, Wiest O, Haldar K. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature. 2015 Apr 30;520(7549):683-7. doi: 10.1038/nature14412
5. Ghorbal M, Gorman M, Macpherson CR, Martins RM, Scherf A, Lopez-Rubio JJ. Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPRCas9 system. Nat Biotechnol. 2014 Aug;32(8):819-21. doi: 10.1038/nbt.2925
Wednesday, 04 September 2024PostDoc l Trypanosoma brucei l York, UK
Postdoctoral Research Associate, York, UK Applications are invited for a postdoctoral researcher for 36 months to characterise the signalling pathways that regulate autophagy, lysosome exocytosis and biomolecular...
Monday, 02 September 2024PostDoc l Malaria Vaccines l Paris, France
mRNA-based malaria vaccines, Paris, France The Malaria Parasite Biology and Vaccines Unit at Institut Pasteur (Prof. Chetan Chitnis), Paris announces a position for a post-doctoral fellow on a project to develop...
Monday, 01 July 2024Next Generation In Parasitology - Workshop
ABOUT SPEAKERS PROGRAMME REGISTRATION CONTACT LOCATION About the workshop ParaFrap is organizing the ParaFrap Next Generation in Parasitology...
Thursday, 20 June 2024PostDoc l Computational Researcher l Montpellier, France
Computational postdoctoral researcher in malaria and erythropoiesis, Montpellier, France The MIVEGEC Lab is seeking a highly motivated and talented postdoctoral researcher to join our team investigating the...
Monday, 29 April 2024MA. Hakimi, laureate of the Excellence Chair in Biology/Health France 2030
[Communiqué] As part of the actions of the Health Innovation Plan 2030, the health component of the France 2030 plan, Mohamed-Ali Hakimi is one of the 22 laureates of an Excellence Chair in Biology/Health, supported to conduct high-level research...
Tuesday, 16 April 2024Seminar - Boris Striepen - May 24
The York Biomedical Research Institute (YBRI) are hosting an online live seminar on Friday 24th May 1-2pm BST as part of their biomedical science seminar series. You are all welcome to attend - registration is required via the...
Friday, 12 April 2024Arthur Talman received an ERC Advanced grant
[Communiqué] Congratulations to Arthur Talman, IRD Research Leader in the MIVEGEC laboratory (Montpellier), who has been awarded an Advanced Grant from the European Research Council (ERC) for the project "TROJAN - Molecular mimicry and immune...
Wednesday, 13 March 2024CNRS Bronze Medal for Ana Rita GOMES
Ana Rita Gomes, a CNRS Research Associate at the Laboratory of Pathogens and Host Immunity in Montpellier, and former Postdoctoral fellow of the LabEx ParaFrap, has been awarded the prestigious CNRS Bronze Medal in 2023. This...
Monday, 11 March 2024PhD Offer l Cryptosporidium l Tours
. PhD Opportunity, Tours, France Supervision Thesis Supervisor: Sonia LAMANDE; Co-Supervisor: Julie TOTTEY Project: FUNTIONAL CHARACTERISATION OF CYSTEINE CATHEPSINS IN THE APICOMPLEXAN PARASITE CRYPTOSPORIDIUM...
Tuesday, 06 February 2024PostDoc l Computational Biologist l Paris, France
Senior PostDoc position : computational biologist, Paris, France The ParSig team (https://research.pasteur.fr/en/team/molecular-parasitology-and-signaling) at the Institut Pasteur in Paris seeks for a highly...
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