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Frédéric BRINGAUD |
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Information |
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Microbiologie Fondamentale et Pathogénicité (MFP) | |
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Energy metabolism of trypanosomes (iMET) | |
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Bordeaux | |
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0000-0003-4552-6877 | |
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This email address is being protected from spambots. You need JavaScript enabled to view it. | |
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http://www.mfp.cnrs.fr/wp/la-recherche/intermediate-and-energy-metabolism-of-trypanosomes-imet/ | |
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@bringaudf | |
Scientific interests and projects |
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Our group has been working for over 25 years on molecular biology and metabolism of trypanosomes, with a particular interest on the central and energy metabolism of the procyclic (PCF) and bloodstream (BSF) forms of Trypanosoma brucei. One of our main objectives is to elucidate the topology of the metabolic network, including the discovery of new metabolic pathways and the understanding regulations between different metabolic branches. The group is one of the few in the field of parasitology to have developed a combination of state-of-the-art nuclear magnetic resonance (NMR) and mass spectrometry (MS) metabolomic technologies to study metabolism of wild-type parasites, as well as a large collection mutants (single, double and triple mutants) covering most of the known branches of the central metabolism. Among our recent major acheivements, we have shown that (1) BSF can grow in medium containing glycerol instead of glucose, while glucose was considered the only carbon source used by the parasite in vivo (Pineda et al., 2018). This open new avenues for understanding parasite metabolism in vivo, as it has recently been described that BSF are more abundant in skin and adipose tissues than in blood. Since the adipocytes present in these organs are excellent glycerol-producers, we study the role of glycerol metabolism in the context of extravascular trypanosomes. (2) Gluconeogenesis occurs in PCF and BSF trypanosomes grown in glucose-free conditions, through unexpected redundant pathways under study (Wargnies et al., 2018). (3) As opposed to most organisms, PCF prefer to metabolise glycerol than glucose, and glycerol metabolism represses glucose consumption through a new mechanism name "metabolic contest" (submitted for publication). Interestingly, phospholipases excreted by PCF can produce glycerol from serum-derived phospholipids that could offer a metabolism benefit in vivo, which is under investigation |
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Top 5 publications of the last 5 years |
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1. Wargnies M., E. Bertiaux, E. Cahoreau, N. Ziebart, A. Crouzols, P. Morand, M. Biran, S. Allmann, J. Hubert, O. Villafraz, Y. Millerioux, N. Plazolles, C. Asencio, L. Riviere, B. Rotureau, M. Boshart, J.-C. Portais & F. Bringaud (2018) Gluconeogenesis is essential for trypanosome development in the tsetse fly vector. PLoS Pathog. 14:e1007502. 10.1371/journal.ppat.1007502 2. Pineda E., M. Thonnus, M. Mazet, A. Mourier, E. Cahoreau, M. Biran, J.-W. Dupuy, C. Massante, S. Allmann, L. Riviere, B. Rotureau, J.-C. Portais & F. Bringaud (2018) Glycerol supports growth of the Trypanosoma brucei bloodstream forms in the absence of glucose: analysis of metabolic adaptations on glycerol-rich conditions. PLoS Pathog. 14:e1007412. 10.1371/journal.ppat.1007412 3. Millerioux Y., M. Mazet, G. Bouyssou, S. Allmann, T.R. Kiema, C. Thapa, M. Biran, N. Plazolles, L. Fouillen, E. Bertiaux, A. Crouzols, R. Wierenga, B. Rotureau, P. Moreau & F. Bringaud (2018) De novo biosynthesis of lipids in the Trypanosoma brucei procyclic form: carbon source preferences and metabolic flux redistributions and essentiality of the leucine degradation pathway in vivo. PLoS Pathog. 14:e1007116. 10.1371/journal.ppat.1007116 4. Suárez Mantilla B., L. Marchese, N.A. Dyer, N. Ejeh, M. Biran, F. Bringaud, M.J. Lehane, A. Acosta-Serrano & A. Silber (2017) Trypanosoma brucei proline metabolism is essential for colonization of the tsetse. PLoS Pathog. 13:e1006158. 10.1371/journal.ppat.1006158 5. Creek D.J., M. Mazet, F. Achcar, J. Anderson, D.-H. Kim, R. Kamour, P. Morand, Y. Millerioux, M. Biran, E. Kerkhoven, U. Chokkathukalam, K.E.V. Burgess, R. Breitling, D.G. Watson, F. Bringaud & M.P. Barrett (2015) Untargeted stable isotope labelled metabolomics reveals glucose to contribute widely to the metabolic network of bloodstream form Trypanosoma brucei. PLoS Pathog. 11:e1004689. 10.1371/journal.ppat.1004689 |
[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs moléculaires de l'invasion des bradyzoïtes et...
LabEx ParaFrap wishes you happiness, health, science and success for 2023. First news from the network this year: the ParaFrap webinars will be back in 2023, as in previous years, every second Thursday of the month at 3pm. If you are not yet on the...
PostDoc position in Biological Sciences / Biochemistry: Mode of action of antimalarial benzylmenadiones at IBMC, Strasbourg, France A renewable 1-year postdoctoral position is open at IBMC (Inserm/CNRS/University...
[Communiqué] Gerald Spaeth, head of the "Molecular Parasitology and Signalling" unit at the Institut Pasteur Paris, has been awarded a Synergy grant from the European Research Council (ERC) for the project "DECOLeishRN - Decoding...
PostDoc position studying host-pathogen interactions at Institut Pasteur, Paris, France A postdoc position is available at the Institut Pasteur in the signalling and host-parasite interactions group, headed by Najma Rachidi, to investigate the...
[Communiqué] The team of Dr Chetan Chitnis from the Institut Pasteur, a partner in LabEx ParaFrap, has studied the blood stage of the Plasmodium falciparum parasite, which causes the most severe and deadly form of malaria, and discovered a...
PhD Position in Single Particle Imaging of P. falciparum Knobs Project Leader Prof. Dr. Michael Lanzer (Heidelberg University Hospital, Centre for Infectious Diseases, Parasitology Unit, INF 324, 69120 Heidelberg, Germany)...
PostDoc position in Biological Chemistry/Biochemistry/Proteomics at University of Strasbourg, France A renewable 6 month post-doctoral position is open at the ECPM (University of Strasbourg) to use activity-based protein...
Dear colleagues,The EMBO Workshop "New frontiers in host-parasite interactions, from cell to organism", supported by...
Position: External Recruitment Competition (permanent position) - Assistant Engineer in biology, life and earth sciences Details:Study of the cytoskeleton in Trypanosoma brucei and Toxoplasma gondii...
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