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Fabrice LAURENT |
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Information |
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Infectiology and Public Health UMR1282 INRA-Tours Univ | |
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Apicomplexa and Mucosal immunity (AIM laboratory) | |
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Tours/Nouzilly | |
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0000-0002-9687-7952 | |
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This email address is being protected from spambots. You need JavaScript enabled to view it. | |
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https://www6.val-de-loire.inrae.fr/infectiologie-santepublique_... | |
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@FabriceLaurent0 | |
Scientific interests and projects |
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General scientific interests: Apicomplexa and Mucosal Immunity (AIM) team is working on two apicomplexan parasites with intestinal tropism, Cryptosporidium and Eimeria. Historically our research on cryptosporidiosis mainly concerned investigations on the protective and pathological immune responses. However, we extend our researches and recently start to characterize the molecular mechanisms that govern Cryptosporidium/intestinal epithelial cell interactions and the long term consequences of the infection on intestinal homeostasis and immune disorders. In man and farm animals, cryptosporidiosis is poorly controlled and we wish to combine two complementary strategies for an efficient control of the disease. Based on strong dependence of functional immune responses for controlling Cryptosporidium we wish to develop immunostimulatory strategies dedicated to neonates in order to strengthen their ability to limit parasite growth. Drug therapies are limited both in human and livestock, we therefore aim to develop new potent molecules to control parasite development. Scientific activities to be developed in the framework of Parafrap: II- Gut physiopathology: Infection of young individuals by C. parvum induces a long-term defect on intestinal gut physiology and this has been linked to the occurrence of Irritable Bowel Syndrome (IBS). We plan to investigate the contribution of Paneth cells (PC) and their antimicrobial peptides on the onset of this intestinal disorder. III- Control strategies: In collaboration with several international teams including Ali Hakimi’s team from Parafrap with whom we recently identified a first promising target (CPSF3) we wish to further develop our therapeutic arsenal against Cryptosporidium, from drug screening to molecular target identification and in vivo final validation (rodent and large animal models). |
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Top 5 publications of the last 5 years |
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1. C. Swale, A. Bougdour, A. Gnahoui-David, J. Tottey, S. Georgeault, F. Laurent, A. Palencia and Mohamed-Ali Hakimi, Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection Science Translational Medicine, 11(517): eaax7161. doi: 10.1126/scitranslmed.aax7161 2. Potiron L, Lacroix-Lamandé S, Marquis M, Levern Y, Fort G, Franceschini I, Laurent F. Batf3-Dependent Intestinal Dendritic Cells Play a Critical Role in the Control of Cryptosporidium parvum Infection. J Infect Dis. 2019 Feb 23;219(6):925-935. doi: 10.1093/infdis/jiy528 3. Diallo MA, Sausset A, Gnahoui-David A, Silva ARE, Brionne A, Le Vern Y, Bussière FI, Tottey J, Lacroix-Lamandé S, Laurent F, Silvestre A. Eimeria tenella ROP kinase EtROP1 induces G0/G1 cell cycle arrest and inhibits host cell apoptosis. Cellular Microbiology. 2019 Jul;21(7):e13027. doi: 10.1111/cmi.13027. 4. Riba A, Olier M, Lacroix-Lamandé S, Lencina C, Bacquié V, Harkat C, Gillet M, Baron M, Sommer C, Mallet V, Salvador-Cartier C, Laurent F, Théodorou V, Ménard S. Microbiota dysbiosis induced by defect of Paneth cells triggers visceral hypersensitivity in mice. Gastroenterology. 2017 Dec;153(6):1594-1606.e2. doi: 10.1111/cmi.12632. 5. de Sablet T, Potiron L, Marquis M, Bussière FI, Lacroix-Lamandé S, Laurent F. Cryptosporidium parvum increases intestinal permeability through interaction with epithelial cells and IL-1β and TNFα released by inflammatory monocytes. Cell Microbiol. 2016 Dec;18(12):1871-1880. 10.1111/cmi.12632. |
[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs moléculaires de l'invasion des bradyzoïtes et...
LabEx ParaFrap wishes you happiness, health, science and success for 2023. First news from the network this year: the ParaFrap webinars will be back in 2023, as in previous years, every second Thursday of the month at 3pm. If you are not yet on the...
PostDoc position in Biological Sciences / Biochemistry: Mode of action of antimalarial benzylmenadiones at IBMC, Strasbourg, France A renewable 1-year postdoctoral position is open at IBMC (Inserm/CNRS/University...
[Communiqué] Gerald Spaeth, head of the "Molecular Parasitology and Signalling" unit at the Institut Pasteur Paris, has been awarded a Synergy grant from the European Research Council (ERC) for the project "DECOLeishRN - Decoding...
PostDoc position studying host-pathogen interactions at Institut Pasteur, Paris, France A postdoc position is available at the Institut Pasteur in the signalling and host-parasite interactions group, headed by Najma Rachidi, to investigate the...
[Communiqué] The team of Dr Chetan Chitnis from the Institut Pasteur, a partner in LabEx ParaFrap, has studied the blood stage of the Plasmodium falciparum parasite, which causes the most severe and deadly form of malaria, and discovered a...
PhD Position in Single Particle Imaging of P. falciparum Knobs Project Leader Prof. Dr. Michael Lanzer (Heidelberg University Hospital, Centre for Infectious Diseases, Parasitology Unit, INF 324, 69120 Heidelberg, Germany)...
PostDoc position in Biological Chemistry/Biochemistry/Proteomics at University of Strasbourg, France A renewable 6 month post-doctoral position is open at the ECPM (University of Strasbourg) to use activity-based protein...
Dear colleagues,The EMBO Workshop "New frontiers in host-parasite interactions, from cell to organism", supported by...
Position: External Recruitment Competition (permanent position) - Assistant Engineer in biology, life and earth sciences Details:Study of the cytoskeleton in Trypanosoma brucei and Toxoplasma gondii...
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