

![]() |
Cyrille BOTTÉ |
|
Information |
||
![]() |
Institute of Advanced Biosciences | |
![]() |
Apicolipid: Membrane biogenesis, lipid synthesis and nutrient acquisition of Apicomplexan parasites and their human host cells | |
![]() |
Grenoble | |
![]() |
0000-0002-2245-536X | |
![]() |
This email address is being protected from spambots. You need JavaScript enabled to view it. | |
![]() |
https://iab.univ-grenoble-alpes.fr/ | |
![]() |
@ApicoLipid | |
Scientific interests and projects |
||
The research team I currently lead (https://NotAllowedScript641a6c589b1a7twitter.com/ApicoLipid @ApicoLipid) as CNRS Research Director focuses on understanding how Apicomplexan parasites acquire lipids and nutrient essential for their propagation and survival within their host cells. Apicomplexa are unicellular eukaryotes and pathogenic agents responsible for major human diseases such as Toxoplasmosis, major chronic disease affecting ~1/3 of the world population and a lethal threat to immunocompromised patients, and (ii) malaria affecting 250 millions people/year, killing ~1/2million/year, mainly children. The renewal of our therapeutic arsenal needed for the eradication of these diseases depends on deciphering metabolic pathways that sustain parasite survival within the host and its environment. Current evidences all point at lipid synthesis and membrane biogenesis as crucial pathways for parasite intracellular development. Major biological questions remain and focus our current attention (i) how are lipids acquired, remodelled and trafficked from the host cell to the parasite and between parasite intracellular compartments? (ii) what is the input of scavenged vs de novo synthesised lipids? (iii) what are the mechanisms of lipid fluxing and trafficking from these two pathways? (iv) how does parasites sense and regulate these pathways to adapt to physiological changes of host nutritional and environmental conditions? (v) what are the parasite lipid signals required for intracellular development? Our laboratory have set up major facilities and equipements that includes a P3* cell culture facility (MESRI-HCB), and a fully independent lipidomic-fluxomic platform encompassed within our P3* (http://gemeli-uga.fr/GEMELI.html), both parts of the core facilities of our Institution at the Université Grenoble Alpes. Our robust expertise and facilities thus allows us to conduct large metabolomics and lipidomics analyses beyond our central scope, on infectious diseases and other models, to determine metabolic signatures or monitoring metabolite fluxes. We currently lead major collaborative projects with national and international partners (LIA University Melbourne/WEHI, CEFIPRA ICGEB New Dehli…). |
||
Top 5 publications of the last 5 years |
||
1. Amiar S, Katris NJ, Berry L, Dass S, Shears MJ, Brunet C, Touquet B, McFadden GI, Yamaryo-Botté Y*, Botté CY*. (2019) Division and adaptation to host nutritional environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelles remodelling, Accepted in Cell Reports, (CELL-REPORTS-D-19-01152) 2. Dubois D, Fernandes S, Amiar S, Dass S, Katris NJ, Botté CY*, Yamaryo-Botté Y*. (2018)(*colast and corresponding) Toxoplasma gondii acetyl-CoA synthetase is involved in fatty acid elongation (of long fatty acid chains) during tachyzoite life stages. J Lipid Res. 59(6):994-1004 3. Shears MJ, MacRae JI, Goodman DG, Mollard VSU, Botté CY *, McFadden GI*. (2017) (*co-last) Characterization of the Plasmodium falciparum and P. berghei glycerol-3-phosphate acyltranferase involved in FASII fatty acid utilization in the malaria parasite apicoplast. Cellular Microbiology 19(1) 4. Amiar S, MacRae JI, Callahan DL, vanDooren GG, Shears MJ, Dubois D, Cesbron-Delauw MF, Maréchal E, McConville MJ, McFadden GI, Yamaryo-Botté Y*, Botté CY *. (2016) The Toxoplasma gondii apicoplast is responsible for bulk phospholipid synthesis mainly via a plantlike glycerol 3-phosphate acyltransferase for lysophosphatidic acid precursor assembly. Plos Pathogens 4;12(8):e1005765 5. Bullen H+, Jia Y+, Yamaryo-Botté Y, Klages J, Carruthers V, Botté CY, Soldati-Favre D. (2016) . Phosphatidic acid-mediated signaling is essential for microneme secretion in Toxoplasma. Cell Host and Microbe 9;19(3):349-60 |
[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs moléculaires de l'invasion des bradyzoïtes et...
LabEx ParaFrap wishes you happiness, health, science and success for 2023. First news from the network this year: the ParaFrap webinars will be back in 2023, as in previous years, every second Thursday of the month at 3pm. If you are not yet on the...
PostDoc position in Biological Sciences / Biochemistry: Mode of action of antimalarial benzylmenadiones at IBMC, Strasbourg, France A renewable 1-year postdoctoral position is open at IBMC (Inserm/CNRS/University...
[Communiqué] Gerald Spaeth, head of the "Molecular Parasitology and Signalling" unit at the Institut Pasteur Paris, has been awarded a Synergy grant from the European Research Council (ERC) for the project "DECOLeishRN - Decoding...
PostDoc position studying host-pathogen interactions at Institut Pasteur, Paris, France A postdoc position is available at the Institut Pasteur in the signalling and host-parasite interactions group, headed by Najma Rachidi, to investigate the...
[Communiqué] The team of Dr Chetan Chitnis from the Institut Pasteur, a partner in LabEx ParaFrap, has studied the blood stage of the Plasmodium falciparum parasite, which causes the most severe and deadly form of malaria, and discovered a...
PhD Position in Single Particle Imaging of P. falciparum Knobs Project Leader Prof. Dr. Michael Lanzer (Heidelberg University Hospital, Centre for Infectious Diseases, Parasitology Unit, INF 324, 69120 Heidelberg, Germany)...
PostDoc position in Biological Chemistry/Biochemistry/Proteomics at University of Strasbourg, France A renewable 6 month post-doctoral position is open at the ECPM (University of Strasbourg) to use activity-based protein...
Dear colleagues,The EMBO Workshop "New frontiers in host-parasite interactions, from cell to organism", supported by...
Position: External Recruitment Competition (permanent position) - Assistant Engineer in biology, life and earth sciences Details:Study of the cytoskeleton in Trypanosoma brucei and Toxoplasma gondii...
© 2023. All rights reserved MLCOM
Notre site LabEx ParaFrap utilise des cookies pour réaliser des statistiques de visites, partager des contenus sur les réseaux sociaux et améliorer votre expérience. En refusant les cookies, certains services seront amenés à ne pas fonctionner correctement. Nous conservons votre choix pendant 30 jours. Vous pouvez changer d'avis en cliquant sur le bouton 'Cookies' en bas à gauche de chaque page de notre site. En savoir plus
Ce site utilise des cookies pour assurer son bon fonctionnement et ne peuvent pas être désactivés de nos systèmes. Nous ne les utilisons pas à des fins publicitaires. Si ces cookies sont bloqués, certaines parties du site ne pourront pas fonctionner.
Ce site utilise des cookies de mesure et d’analyse d’audience, tels que Google Analytics et Google Ads, afin d’évaluer et d’améliorer notre site internet.
Ce site utilise des composants tiers, tels que NotAllowedScript641a6c589a936ReCAPTCHA, Google NotAllowedScript641a6c589a466Maps, MailChimp ou Calameo, qui peuvent déposer des cookies sur votre machine. Si vous décider de bloquer un composant, le contenu ne s’affichera pas
Des plug-ins de réseaux sociaux et de vidéos, qui exploitent des cookies, sont présents sur ce site web. Ils permettent d’améliorer la convivialité et la promotion du site grâce à différentes interactions sociales.
Ce site web utilise un certain nombre de cookies pour gérer, par exemple, les sessions utilisateurs.