Multidisciplinary PhD opportunity in the fields of
infectious diseases, gene regulations and molecular signalisation.

 Fully Funded 4-Year PhD at the University of York 

A fully funded PhD opportunity is available at the University of York through the Medical Research Council (MRC) DiMeN Doctoral Training Partnership (DTP).
This multidisciplinary project brings together the fields of infectious diseases, gene regulation, and molecular signalisation.

 Research Focus 

Join the University of York to investigate the biology of African Trypanosomes (Trypanosoma brucei) — parasites responsible for Sleeping Sickness and Nagana, which together cost the global economy more than $4.5 billion each year.

This project sits at the intersection of molecular biology and infection research.
T. brucei depends heavily on post-transcriptional gene regulation for its survival and life cycle progression, as it lacks extensive transcriptional control.

 Project Goal 

You will use cutting-edge technology to study the diversity, architecture, and regulation of biomolecular condensates, essential membraneless organelles.
Recent findings suggest that these condensates play a key role in the parasite’s adaptability and transmission to diverse hosts.

 Why Apply 

• Gain expertise in molecular mechanisms and advanced technologies such as:

  • Kinome-wide RNAi library and CRISPR-mediated single-point mutagenesis

  • Volumetric electron microscopy

  • Next-Generation Sequencing (NGS)

• Join a vibrant research environment at the University of York and the York Biomedical Research Institute.

• Work under the supervision of Dr. Mathieu Cayla and Dr. Pegine Walrad.

• Become part of a diverse community of PhD students across the North of England (Universities of Leeds, Liverpool, Newcastle, York, and Sheffield) researching major global health challenges.

• Fully funded for 4 years through the MRC DiMeN DTP, covering tuition fees, annual stipend, and project costs.
  

 Application Information 

Application Deadline: 4th December 2025

Applications must be submitted via the DiMeN website:
👉 www.dimen.org.uk

For full details, see the advert on Find A PhD:
👉 Project Page on Find A PhD

📄 DiMeN_DTP_-_PhD_project.pdf

Postdoc (M/F) in molecular and biochemical parasitology (Toxoplasma gondii)

A 24-month post-doctoral position starting on January 2026 and funded by the French National Research Agency (ANR) is available in the in the Laboratory of Pathogens and Host Immunity (LPHI) under the supervision of Sébastien Besteiro (https://lphi.umontpellier.fr/research-teams/cell-biology-of-apicomplexan-parasites/besteiro/).

Our research: Toxoplasma gondii is a ubiquitous intracellular parasite that can cause severe pathology, known as toxoplasmosis, particularly following reactivation in immunocompromised hosts or through congenital transmission. Currently, few drugs are available to treat acute toxoplasmosis, and notably, no drug exists to eliminate the encysted, persistent form of T. gondii. We are investigating the parasite's unique metabolic features that could be targeted to develop specific inhibitors.

Job description: this funded position aims to identify novel parasite-specific proteins that contain an iron–sulfur (Fe–S) cluster cofactor, perform their in-depth functional characterization, and uncover new potential drug targets. The role will involve the use of molecular tools for genetic engineering of transgenic parasites, advanced imaging techniques, and the implementation of novel chemoproteomics protocols. Parasite culture and molecular laboratory techniques are an integral part of the daily routine.

Qualifications: a PhD in microbiology, cell biology, or biochemistry; strong knowledge in biochemistry and/or parasitology; excellent organizational and problem-solving skills; the ability to lead an ambitious research project; strong written and oral communication skills in English; the ability to work both independently and collaboratively; and a strong motivation to pursue an academic career.

The LPHI research lab: this is a multidisciplinary Research Unit affiliated to the CNRS (UMR 5294)/INSERM (UA 15)/University of Montpellier, dedicated to the study of infectious processes and host immune response. Research groups at the LPHI conduct projects ranging from the in vitro study of basic biological processes to the global analysis of field samples and the mathematical modelling of cellular interactions.

The University of Montpellier: established in 1220, it is one of the oldest universities in the world. With more than 50,000 students, 73 affiliated research facilities and 15 cutting-edge technical platforms, it is recognised as one of the leading Universities in France.

Montpellier: a vibrant Mediterranean city rich in arts and culture, located between the sea and a beautiful countryside that offers a great range of hiking options!

Application

See details in the PDF file.

Post-doc_postion_Besteiro_lab.pdf

Postdoc (M/F) Molecular and cell biology in Trypanosoma brucei

A 24-month post-doctoral position starting on November 1^st 2025 (or before) and funded by the French National Research Agency (ANR) is available in the Microbiologie Fondamentale et Pathogénicité (MFP) laboratory in Bordeaux under the supervision of Dr Frédéric Bringaud (iMET team: https://www.mfp.cnrs.fr/wp/la-recherche/intermediate-and-energy-metabolism-of- trypanosomes-imet/).

Project: TrypaDiff - Glycerol, a new key player in the trypanosome parasite

Trypanosoma brucei is an extracellular parasite responsible for sleeping sickness in Africa and transmitted by a blood-feeding insect vector, the tsetse fly. In its mammalian host, the rapidly dividing slender forms predominate in the blood and tissues. At the peak of parasitaemia, slender forms differentiate into growth-arrested stumpy forms (ST) to protect the host by preventing high parasitaemia. Slender to stumpy differentiation relies on a quorum sensing mechanism triggered by the accumulation of di- and tripeptides produced by oligopeptidases excreted by the parasites. The current model of T. brucei transmission from mammals to the insect vector emphasises the key role of the quorum sensing-derived stumpy forms (ST-QS) produced in the blood. However, this may not be the only differentiation pathway.

Our recent unpublished data showed that glycerol, which is abundant in the skin and adipose tissues where the parasites also reside, induces differentiation of slender to stumpy-like forms (ST-Glyc), which are competent for differentiation into parasitic forms present in the insect. We thus propose a rational working hypothesis, in which the glycerol present in the skin would induce the production of ST-Glyc mostly responsible for the parasite transmission to the fly.

To study this new paradigm, our ANR-funded consortium composed of Dr Frédéric Bringaud (Bordeaux, coordinator of the TrypaDiff project), Dr Brice Rotureau (Institut Pasteur Paris - IPP) and Dr Lucy Glover (IPP) will (i) characterize glycerol-induced ST-Glyc forms, (ii) determine the biological relevance of these parasites, and (iii) characterize the signaling pathway(s) involved in their glycerol-induced differentiation. This program will contribute to a better understanding of the developmental biology of trypanosomes responsible for human and domestic animal diseases and will highlight possible new ways to control parasite transmission.

Experimental approaches

In vitro culture and differentiation of trypanosomes, preparation of cell samples for multiomics analyses (proteomics, metabolomics, genomics, single cell transcriptomics) performed in collaboration with specialised platforms, analysis of candidate genes involved in the glycerol-induced differentiation process by reverse genetic (KO and epitope-tagging using CRISPR-cas9, conditional RNAi knockdown and overexpression).

Requirements

Candidates with at least a PhD in Biological Science, especially in Parasitology or Cell Biology are encouraged to postulate. Highly motivated and autonomous candidates are wanted. Skills in cell culture and molecular biology would be appreciated.

Application

Applicants should send a CV, a bibliography, a motivation letter and the names of three references in a single pdf file to Dr Frédéric Bringaud before September 15^th 2025 (see details in the PDF file).

Post-doc_call_2025.pdf

Postdoc (M/F) in molecular biology in P. falciparum

Workplace: MONTPELLIER

Contract Period: 24 months

Expected date of employment: 1 October 2025

Proportion of work: Full Time

Remuneration: Starting from 3021.50€ gross per month, adjustable based on experience.

Desired level of education: Doctorate

Missions

The postdoctoral project aims to identify and study the molecular actors and mechanisms involved in the regulation of gene expression in the mitochondrion and apicoplast of the human malaria parasite, P. falciparum.

Main activities

- Project management

- Design and development of experiments (transfection, microscopy, transcriptomics, proteomics...).

- P. falciparum cell culture

- Data analysis and presentation (written and oral)

- Literature monitoring

- Dissemination of knowledge in seminars and conferences

Qualifications

- PhD in molecular biology or parasitology

- Strong knowledge in gene expression regulation and/or parasitology

- Excellent problem-solving skills and the ability to lead an ambitious research project

- Good written and oral communication skills in English

- Ability to work autonomously and within a collaborative team

Desired skills

- Experience in research on P. falciparum

- Experience in cell culture

- Expertise in one or more techniques (e.g., RNA-seq, Nanopore, IFA, protein-protein interactions, etc.)

- Familiarity with bioinformatics (optional)

- Willingness to supervise students

Work Context

The LPHI is a Mixed Research Unit CNRS UMR 5294, INSERM UA 15, and the University of Montpellier, dedicated to the study of infectious processes and host immune response. The postdoc will join the ATIP-Avenir team entitled "Post-transcriptional Regulation of Gene Expression in P. falciparum" under the direct supervision of T. Hollin.

The LPHI laboratory offers an excellent intellectual environment for research in microbiology/parasitology, and the University of Montpellier provides numerous technical platforms that are essential for the project.

Additionally, the LPHI includes 4 teams working on parasites (Toxoplasma and Plasmodium) and thus offers a stimulating work environment and a wide range of skills and knowledge to acquire in parasitology.

We strive to create an environment where all individuals are valued, respected, and supported.

The position is located in a sector under the protection of scientific and technical potential (PPST), and therefore requires, in accordance with the regulations, that your arrival is authorized by the competent authority of the MESR.

Constraints and risks

Work in Containment Level 3 Laboratory.

For more information

https://lphi.umontpellier.fr/research-teams/team-hollin/

Please send your application to: thomas.hollin [at] umontpellier.fr