Project Title : "Plasmodium falciparum: Characterization of novel enzymes responsible for the lipid processing pathway."

Project PI : Cyrille Botté   Co-PI : Dominique Mazier

Lab : Apicolipid : Membrane biogenesis in Malaria and Toxoplasmosis, IAB UMR5309-CNRS-INSERM, Université Grenoble Alpes

BACKGROUND

• PhD in the Dr. Ross Waller Lab ⎪ University of Melbourne, Australia / University of Cambridge, UK
• Bachelor of Science ⎪ University of Melbourne, Australia

PUBLICATIONS

Bansal, P., Antil, N., Kumar, M., Yamaryo-Botté, Y., Rawat, R.S., Pinto, S., Datta, K.K., Katris, N.J., Botté, C.Y., Prasad, T.S.K., Sharma, P., (2021). Protein kinase TgCDPK7 regulates vesicular trafficking and phospholipid synthesis in Toxoplasma gondii. PLoS Pathog [6.2] 17, e1009325. doi: 10.1371/journal.ppat.1009325

Katris, N.J., Yamaryo-Botte, Y., Janouškovec, J., Shunmugam, S., Arnold, C.-S., Yang, A.S.P., Vardakis, A., Stewart, R.J., Sauerwein, R., McFadden, G.I., Tonkin, C.J., Cesbron-Delauw, M.-F., Waller, Ross.F., Botte, C.Y., (2020). Rapid kinetics of lipid second messengers controlled by a cGMP signalling network coordinates apical complex functions in Toxoplasma tachyzoites. bioRxiv [preprint]. doi: 10.1101/2020.06.19.160341

Amiar, S., Katris, N.J., Berry, L., Dass, S., Duley, S., Arnold, C.-S., Shears, M.J., Brunet, C., Touquet, B., McFadden, G.I., Yamaryo-Botté, Y., Botté, C.Y., (2020). Division and Adaptation to Host Environment of Apicomplexan Parasites Depend on Apicoplast Lipid Metabolic Plasticity and Host Organelle Remodeling. Cell Rep [8.1] 30, 3778-3792.e9. doi: 10.1016/j.celrep.2020.02.072

Yang, L., Uboldi, A.D., Seizova, S., Wilde, M.L., Coffey, M.J., Katris, N.J., Yamaryo-Botte, Y., Kocan, M., Bathgate, R.A.D., Stewart, R.J., McConville, M.J., Thompson, P.E., Botte, C.Y., Tonkin, C.J., (2019). An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca(2+) signalling and motility in Toxoplasma gondii. J Biol Chem [4.1]. doi: 10.1074/jbc.RA118.005491

Dubois, D., S. Fernandes, S. Amiar, S. Dass, N. J. Katris, C. Y. Botte and Y. Yamaryo-Botte (2018). "Toxoplasma gondii acetyl-CoA synthetase is involved in fatty acid elongation (of long fatty acid chains) during tachyzoite life stages." J Lipid Res [4.8] 59(6): 994-1004. [Link]

Uboldi, A. D., M. L. Wilde, E. A. McRae, R. J. Stewart, L. F. Dagley, L. Yang, N. J. Katris, S. V. Hapuarachchi, M. J. Coffey, A. M. Lehane, C. Y. Botte, R. F. Waller, A. I. Webb, M. J. McConville and C. J. Tonkin (2018). "Protein kinase A negatively regulates Ca2+ signalling in Toxoplasma gondii." PLoS Biol [9.2] 16(9): e2005642. [Link]