Mobile menu

Alliance Française contre les Maladies Parasitaires


cs

Project Title : "Identification of new compounds with activity against Toxoplasma gondii and Plasmodium. Applications to develop new anti-parasitic agents directed to novel targets"

Project PI : Mohamed-Ali Hakimi  Co-PI : Cyrille Botté

Lab : Host-pathogen interactions & Immunity to infections, IAB U1209-INSERM-CNRS, Université Grenoble Alpes

In 2C 128px R

BACKGROUND

  • Post-doc in EMBL-Grenoble Outstation, Grenoble, France (2015-2016)
  • PhD student in Unit of Virus Host Cell Interactions (UVHCI UMR3265) Grenoble, France (2012-2015)

POSITION AFTER PARAFRAP TRAINING

Postdoctoral researcher at CNRS, IAB, Grenoble, France

PUBLICATIONS

Dard, C., Swale, C., Brenier-Pinchart, M.-P., Farhat, D.C., Bellini, V., Robert, M.G., Cannella, D., Pelloux, H., Tardieux, I., Hakimi, M.-A., (2021). A brain cyst load-associated antigen is a Toxoplasma gondii biomarker for serodetection of persistent parasites and chronic infection. BMC Biology [6.8] 19, 25. doi: 10.1186/s12915-021-00959-9

Farhat, D.C., Bowler, M.W., Communie, G., Pontier, D., Belmudes, L., Mas, C., Corrao, C., Coute, Y., Bougdour, A., Lagrange, T., Hakimi, M., Swale, C. (2021). A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental genes partitioning in Toxoplasma. bioRxiv [preprint] 2021.02.23.432502. doi: 10.1101/2021.02.23.432502

Bellini, V., Swale, C., Brenier-Pinchart, M.-P., Pezier, T., Georgeault, S., Laurent, F., Hakimi, M.-A., Bougdour, A., (2020). Target identification of an antimalarial oxaborole identifies AN13762 as an alternative chemotype for targeting CPSF3 in apicomplexan parasites. iScience [4.4]  doi: 10.1016/j.isci.2020.101871

Farhat, D.C., Swale, C., Dard, C., Cannella, D., Ortet, P., Barakat, M., Sindikubwabo, F., Belmudes, L., De Bock, P.-J., Couté, Y., Bougdour, A., Hakimi, M.-A., (2020). A MORC-driven transcriptional switch controls Toxoplasma developmental trajectories and sexual commitment. Nat Microbiol [14.6] 1–14. doi: 10.1038/s41564-020-0674-4

Swale, C., A. Bougdour, A. Gnahoui-David, J. Tottey, S. Georgeault, F. Laurent, A. Palencia and M.-A. Hakimi (2019). "Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection." Sci Transl Med [17.2] 11(517): eaax7161. [PDF]