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Project Title : "Role of the unusual peroxisomal/glycosomal sequestration of cytosolic metabolic pathways in trypanosomes" Project PI : Frédéric Bringaud Co-PI : Cyrille Botté Lab : Intermediate and energy metabolism of trypanosomes, UMR5234 CNRS, Bordeaux University |
BACKGROUND
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POSITION AFTER PARAFRAP TRAINING Postdoctoral researcher at IRCM (Institut de Recherche en Cancérologie de Montpellier), France - Since March 2021 |
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PUBLICATIONS Villafraz, O., Biran, M., Pineda, E., Plazolles, N., Cahoreau, E., Souza, R.O.O., Thonnus, M., Allmann, S., Tetaud, E., Rivière, L., Silber, A.M., Barrett, M.P., Zíková, A., Boshart, M., Portais, J.-C., Bringaud, F., (2021b). Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline. PLoS Pathog [6.2] 17, e1009204. doi: 10.1371/journal.ppat.1009204 Villafraz, O., Baudouin, H., Mazet, M., Kulyk, H., Dupuy, J.-W., Pineda, E., Botté, C., Inaoka, D., Portais, J.-C., Bringaud, F., (2021a). The trypanosome UDP-glucose pyrophosphorylase is imported by piggybacking into glycosomes where unconventional sugar nucleotide synthesis takes place. bioRxiv [preprint] 2021.02.17.431754. doi: 10.1101/2021.02.17.431754 Michels, P.A.M., Villafraz, O., Pineda, E., Alencar, M.B., Cáceres, A.J., Silber, A.M., Bringaud, F., (2021). Carbohydrate metabolism in trypanosomatids: new insights revealing novel complexity, diversity and species-unique features. Exp Parasitol [1.7] 108102. doi: 10.1016/j.exppara.2021.108102 Wargnies, M., Plazolles, N., Schenk, R., Villafraz, O., Dupuy, J.-W., Biran, M., Bachmaier, S., Baudouin, H., Clayton, C., Boshart, M., Bringaud, F., (2021). Metabolic selection of a homologous recombination mediated gene loss protects Trypanosoma brucei from ROS production by glycosomal fumarate reductase *. J Biol Chem [4.2] 0, 100548. doi: 10.1016/j.jbc.2021.100548 Allmann, S., Wargnies, M., Cahoreau, E., Biran, M., Plazolles, N., Morand, P., Pineda, E., Kulyk, H., Asencio, C., Villafraz, O., Rivière, L., Tétaud, E., Rotureau, B., Mourier, A., Portais, J.-C., Bringaud, F., (2019). “Metabolic contest”, a new way to control carbon source preference. bioRxiv [preprint] 800839. doi: 10.1101/800839 Wargnies, M., E. Bertiaux, E. Cahoreau, N. Ziebart, A. Crouzols, P. Morand, M. Biran, S. Allmann, J. Hubert, O. Villafraz, Y. Millerioux, N. Plazolles, C. Asencio, L. Rivière, B. Rotureau, M. Boshart, J.-C. Portais and F. Bringaud (2018). "Gluconeogenesis is essential for trypanosome development in the tsetse fly vector." PLoS Pathog [6.6] 14(12): e1007502. doi: 10.1371/journal.ppat.1007502 |