PostDoc position : Identify new repository molecules against Cryptosporidium, Tours, France 

The lab seeks to hire a highly motivated candidate to work on the identification of new repository molecules against Cryptosporidium and decipher their mechanism of action. The position is funded by a French ANR grant hold by F Laurent (INRAE) and Ali Hakimi laboratory (CNRS Grenoble). The salary is based on the INRAE remuneration grade table for an experienced post-doc. The contract will be for 18 months, extendable up to 2 years. Dayto- day work will be carried out at INRAE Tours-Nouzilly, with possible experiments at IAD Grenoble. The contract is open and allows immediate recruitment. The project includes drug screening, in vitro and in vivo assays on various mouse models, target validation with transgenic Cryptosporidium parasites.

Team

The AIM team (Apicomplexa and Mucosal Immunity) studies the Biology of Cryptosporidium and Eimeria, host-immune responses and control means

Prerequisites

Expertise in the following areas will be very appreciated:

• molecular parasitology (protozoans)
• Cell culture o Animal experimentation (mouse)
• Microbiota analysis
• Ability to work self-motivated and perform independent research with national and international collaborators
• Good verbal and written English skills.

Application

Send your application (motivation letter, CV (including 2 references and short description of previous experiences in relation to this post-doc position) to Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser..

Proposition_de_post-doc_sept_2023.pdf

Emerging Leader Research Fellow, Oxford Brookes University, UK 

The Oxford Brookes University offers an opportunity to develop an independent research group in molecular parasitology/protistology through a five-year research Fellowship.

They are looking for a motivated early-career researcher with a track record in the application of molecular parasitology/protistology with advanced bioimaging/image analysis.

https://my.corehr.com/pls/oburecruit/erq_jobspec_details_form.jobspec?p_id=147380

The Fellow will join a dynamic parasitology grouping that utilises a combination of cutting-edge molecular approaches with advanced bioimaging to dissect the fundamental biology of a wide-range of parasites including trypanosomes, Leishmania, Plasmodium, Eimeria.

The appointed Research Fellow will be provided with a 5-year 100% research position providing long-term, flexible support to develop an independent research career. He will be assigned a mentor in the department will have access to high-quality professional development and networking opportunities as well as competitive internal pump-priming, research funding and fully funded studentships.

PostDoc position : Gene regulation/ DNA low complexity regions-DNA binding proteins, Montpellier, France 

The post-doc project aims to investigate the role of Low Complexity Regions in regulation of gene expression in P. falciparum (Menichelli et al., 2021) and the identification of proteins regulating this process. The position is funded by an ANR grant and the salary based on the CNRS remuneration grade table. The contract will be for 2 years starting spring/summer 2023.

Team

The Lopez-Rubio lab (http://lopezrubiolab.eu/): The goal of the team research is to understand molecular mechanisms of gene expression in Plasmodium falciparum, the causative agent of malaria, using cutting edge technologies.

The group is based within the LPHI unit, in the University of Montpellier, France.

The team investigates Plasmodium falciparum  nuclear biology and is part of the LabEx ParaFrap. https://lphi.umontpellier.fr/en/lphi-teams/plasmodium-genome-plasticity

Prerequisites

• A PhD
• Expertise in one of the following areas will be very appreciated:
  • molecular biology
  • molecular parasitology
  • gene regulation, chromatin biology and biochemistry; 
• Ability to work self-motivated and as a team player in an international environment;
• Good verbal and written English skills;

Application

Send your application (motivation letter, CV, name of two referees and transcripts in one PDF) by email to Jose-Juan Lopez-Jubio.

PostDocDNAmontpellier.pdf

PostDoc position : Cross-talk between stress response and infection in dendritic cells at Institut Pasteur Lille, France 

We seek to hire a highly motivated candidate to work on the role of the Unfolded Protein Response (UPR) in modulating type 1 conventional dendritic cell (cDC1) functions in the context of Toxoplasma gondii infection. We recently unravelled that induction of the IRE1 pathway of the UPR is essential to activate key cDC1 functions and establish an efficient T-cell mediated control of parasite dissemination during acute toxoplasmosis (Poncet A et al. EMBO R, 2021, PMID: 33586853). We now aim to identify the involved molecular mechanisms, focusing on the cross-talk between changes in lipid metabolism induced by the infection and UPR-mediated regulation of cDC1 maturation and MHC-I antigen presentation. To this aim transgenic mice, in vitro cDC1 models and transgenic T. gondii strains will be used. The study will combine immuno-phenotyping techniques, metabolic assays, cellular biology and transcriptomic approaches.

The CIIL is a dynamic research center located in the Pasteur Institute of Lille that comprises internationally recognized groups focusing on immunity to infections and microbiology (https://ciil.fr/). The project is also embedded in a research consortium consisting of experts in UPR and Immunity (S. Janssens, IRC-VIB, Ghent) and in DC biology and T cell responses in the context of infections by intracellular parasites (N. Blanchard, Infinity, Toulouse). The candidate will be an active part of this consortium and will interact and collaborate with the other partners.

Highly motivated scientists with a strong interest in host-pathogen interactions are encouraged to apply. The candidate should have a PhD in Life Sciences with a strong knowledge in immunology. Experience with animal experimentation and flow cytometry is mandatory. Experience in imaging techniques would also be appreciated. Good writing and oral communication skills will be needed. The candidate should have demonstrated initiative, problem-solving attitude, and ability to work well both independently and as a team member.

CV, list of publications, short description of previous research projects and experience, and contact information for two referees should be sent by email to: sabrina.marion (at) pasteur-lille.fr.

post-doc_offer_Institut_Pasteur_Lille.pdf