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Project Title : "Synthesis of chemical tools for tracking lead antiparasitic drugs and their metabolites generated in targeted parasites by nanoSIMS- and fluorescence confocal- imaging & metabolomics" Project PI : Elisabeth Davioud-Charvet Co-PI : Stéphanie Blandin Lab : Laboratoire de Chimie Bioorganique et Médicinale, Strasbourg |
POSITION AFTER PARAFRAP TRAINING Postdoctoral researcher in Guangzhou, China |
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PUBLICATIONS Cichocki, B.A., Donzel, M., Heimsch, K.C., Lesanavičius, M., Feng, L., Montagut, E.J., Becker, K., Aliverti, A., Elhabiri, M., Čėnas, N., Davioud-Charvet, E., (2021). Plasmodium falciparum Ferredoxin-NADP+ Reductase-Catalyzed Redox Cycling of Plasmodione Generates Both Predicted Key Drug Metabolites: Implication for Antimalarial Drug Development. ACS Infect Dis [4.6] doi: 10.1021/acsinfecdis.1c00054 Feng, L., Pomel, S., Latre de Late, P., Taravaud, A., Loiseau, P.M., Maes, L., Cho-Ngwa, F., Bulman, C.A., Fischer, C., Sakanari, J.A., Ziniel, P.D., Williams, D.L., Davioud-Charvet, E., (2020). Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections. Molecules [3.3] 25, 5075. doi: 10.3390/molecules25215075 Feng, L., D. A. Lanfranchi, L. Cotos, E. Cesar-Rodo, K. Ehrhardt, A.-A. Goetz, H. Zimmermann, F. Fenaille, S. A. Blandin and E. Davioud-Charvet (2018). "Synthesis of plasmodione metabolites and 13C-enriched plasmodione as chemical tools for drug metabolism investigation." Org Biomol Chem [3.6] 16(15): 2647-2665. [Link] Rodo, E. C., L. Feng, M. Jida, K. Ehrhardt, M. Bielitza, J. Boilevin, M. Lanzer, D. L. Williams, D. A. Lanfranchi and E. Davioud-Charvet (2016). "A Platform of Regioselective Methodologies to Access Polysubstituted 2-Methyl-1,4-naphthoquinone Derivatives: Scope and Limitations." European Journal of Organic Chemistry [3.1] 2016(11): 1982-1993 . [Link] |