Project Title : "Investigations on the mechanisms of hypnozoite quiescence and activation in the malaria parasites Plasmodium vivax & P. cynomolgi"

Project PI : Dominique Mazier  Co-PI : Artur Scherf

Thesis defense : 01/12/2016 

Lab : Malaria: identification and pre-clinical validation of novel therapeutics, CIMI, Paris

BACKGROUND

• Business Foundation Certificate, INSEA - France (2017)
• Doctor in Industrial Pharmacy, University of Messina - Italy (2006-2011) 

POSITIONS AFTER PARAFRAP TRAINING

• Postodoctoral researcher in Artur Scherf Lab, Pasteur Institute, Paris - France - (2017)
• Postdoctoral researcher in Kappe Lab, Seattle Children's, USA (since 2018)

PUBLICATIONS

Zanghi, G., S. S. Vembar, S. Baumgarten, S. Ding, J. Guizetti, J. M. Bryant, D. Mattei, A. T. R. Jensen, L. Renia, Y. S. Goh, R. Sauerwein, C. C. Hermsen, J. F. Franetich, M. Bordessoulles, O. Silvie, V. Soulard, O. Scatton, P. Chen, S. Mecheri, D. Mazier and A. Scherf (2018). "A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection." Cell Rep [8.3] 22(11): 2951-2963. [Pubmed]

Cubi, R., S. S. Vembar, A. Biton, J. F. Franetich, M. Bordessoulles, D. Sossau, G. Zanghi, H. Bosson-Vanga, M. Benard, A. Moreno, N. Dereuddre-Bosquet, R. Le Grand, A. Scherf and D. Mazier (2017). "Laser capture microdissection enables transcriptomic analysis of dividing and quiescent liver stages of Plasmodium relapsing species." Cell Microbiol [4.5] 19(8). [Pubmed]

Chen, P. B., S. Ding, G. Zanghi, V. Soulard, P. A. DiMaggio, M. J. Fuchter, S. Mecheri, D. Mazier, A. Scherf and N. A. Malmquist (2016). "Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites." Sci Rep [5.2] 6: 21802. [Pubmed]

Barata, L., P. Houze, K. Boutbibe, G. Zanghi, J. F. Franetich, D. Mazier and J. Clain (2016). "In Vitro Analysis of the Interaction between Atovaquone and Proguanil against Liver Stage Malaria Parasites." Antimicrob Agents Chemother [4.5] 60(7): 4333-4335. [Pubmed]

Soulard, V., H. Bosson-Vanga, A. Lorthiois, C. Roucher, J. F. Franetich, G. Zanghi, M. Bordessoulles, M. Tefit, M. Thellier, S. Morosan, G. Le Naour, F. Capron, H. Suemizu, G. Snounou, A. Moreno-Sabater and D. Mazier (2015). "Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice." Nat Commun [11.5] 6: 7690. [Pubmed]