![]() |
Nicolas BLANCHARD |
|
Information |
||
![]() |
Toulouse Institute for Infectious and Inflammatory Diseases | |
![]() |
EPIIC: Eukaryotic Pathogens: Inflammation, T cell Immunity and Chemoresistance | |
![]() |
Toulouse | |
![]() |
0000-0002-4924-2161 | |
![]() |
Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser. | |
![]() |
https://www.infinity.inserm.fr/en/research-teams/team-8-n-blanchard/ | |
Scientific interests and projects |
||
General scientific interests We foresee two activities within the Parafrap consortium: 2- implement a ‘forward vaccinology’ approach based on Plasmodium falciparum immunopeptidome characterization. The goal is to identify and prioritize candidate antigens for a blood stage malaria vaccine. |
||
Top 5 publications of the last 5 years |
||
1. Salvioni A, Belloy M, Lebourg A, Bassot E, Cantaloube-Ferrieu V, Vasseur V, Blanié S, Liblau RS, Suberbielle E, Robey EA, Blanchard N. Robust control of a brain-persisting parasite through MHC I presentation by infected neurons. Cell Reports 2019 Jun 11;27(11):3254-3268.e8. doi: 10.1016/j.celrep.2019.05.051. 2. Bonnart C, Feuillet G, Vasseur V, Cénac N, Vergnolle N*, Blanchard N* (* = co-senior). Toxoplasma gondii infection promotes gut inflammation through Protease Activated Receptor 2 independently from IFNγ and TNFα. Parasite Immunol 2017 Nov;39(11). doi: 10.1111/pim.12489. 3. Draheim M, Wlodarczyk MF, Crozat K, Saliou JM, Alayi TD, Tomavo S, Hassan A, Salvioni A, Demarta-Gatsi C, Sidney J, Sette A, Dalod A, Berry A, Silvie O, Blanchard N. Profiling MHC II immunopeptidome of blood stage malaria reveals that cDC1 control the functionality of parasite-specific CD4 T cells. EMBO Mol Med 2017 Sep 21. pii: e201708123. doi: 10.15252/emmm.201708123. 4. Cebrian I, Croce C, Guerrero NA, Blanchard N*, Mayorga LS*. (* = co-senior). Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells. EMBO Rep. 2016 Dec;17(12):1753-1765. doi: 10.15252/embr.201642358. 5. Lopez J, Bittame A, Massera C, Vasseur V, Effantin G, Valat A, Buaillon C, Allart S, Fox BA, Rommereim LM, Bzik DJ, Schoehn G, Weissenhorn W, Dubremetz JF, Gagnon J, Mercier C, Cesbron-Delauw MF, Blanchard N. Intravacuolar membranes regulate CD8 T cell recognition of membrane-bound Toxoplasma gondii protective antigen. Cell Reports 2015 Dec 15, 13, 1–14. doi: 10.1016/j.celrep.2015.11.001. |