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Alliance Française contre les Maladies Parasitaires


06 Pasteur

PostDoc position studying host-pathogen interactions at Institut Pasteur, Paris, France 

A postdoc position is available at the Institut Pasteur in the signalling and host-parasite interactions group, headed by Najma Rachidi, to investigate the mechanisms by which the parasite modulates host cell signalling, through the study of Leishmania casein kinase 1.

Team:

The project will be developed under the supervision of Dr Najma Rachidi (https://research.pasteur.fr/en/member/najma-rachidi/), PI of the signalling and host-parasite interactions group at the Institut Pasteur in Paris. Institut Pasteur is an international and multi-disciplinary research centre with access to state-of-the-art technologies RNAseq, imaging, electron microscopy...

Project:

During infection, Leishmania parasites release effector molecules via extracellular vesicles to modify their host cell and insure their survival. We are studying one of these effectors, Leishmania Casein Kinase 1, a signalling protein kinase essential for intracellular parasite survival. Our in vitro data suggest that this kinase might fulfil a significant part of its function in the macrophage, by regulating processes such as trafficking, translation or apoptosis; processes also modulated during Leishmania infection. Our data suggests that Leishmania Casein Kinase 1 is an important player in host-parasite interactions as well as an important target for anti-leishmanial drug therapy. The project, part of an ANR, will combine genome editing, siRNA, cutting-edge microscopy and the development of an innovative method to follow the dynamic of infection and its signalling signature with the aim to identify the L-CK1.2 host substrates essential for Leishmania infection. For more details about our work, visit https://research.pasteur.fr/en/team/signalling-and-host-parasite-interactions/.  

Candidate eligibility requirements:

We are looking for a motivated post-doctoral researcher with a strong background in cell culture as well as knockout or knockdown genes (CRISPR Cas9, siRNA and ShRNA) in mammalian cells (cell lines and primary cells). A background in parasitology is not required but would be a bonus. The candidate should be able to work in a multi-disciplinary environment, have a solid record of scientific achievement and a decent level in English. The contract is for two years but the applicant will be strongly encouraged to apply for external and/or internal fellowships.

Application:

Please send your Please send a cover letter, a CV with a publication list and three references to Najma Rachidi.
Applications should be sent before November 15th, with a starting date for the postdoc, beginning 2023.

pdfPostdoc_Pasteur_Rachidi.pdf