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Alliance Française contre les Maladies Parasitaires


 

Projet: 
The malaria parasite relies on phospholipid (PL) metabolism to meet the massive need for membrane biogenesis during its development. The three main PLs of the parasite are essential for parasite survival and synthesized through several connected pathways. Recent analyses of the Plasmodium falciparum PL metabolism have raised new fundamental questions about the sources of PLs, the links between the multiple pathways and the existence of some specific enzymatic steps. This ARN-funded project aims at providing better understanding of the interplay between the multiple and interconnected PL pathways leading to the identification of future putative therapeutic targets. We will analyse the metabolic adaptations of the parasite in response to controlled disturbances such as genetic modifications or inhibitor effects. Our approaches combine molecular biology, Plasmodium genetics, lipidomics and structural biology.

Encadrement:
Pr. Rachel Cerdan, Laboratory of Pathogen Host Interactions (LPHI), University of Montpellier, CNRS, Montpellier, FRANCE

Qualifications et expériences:

Applicants should hold a PhD in Biochemistry and have strong interest in metabolism, regulation of metabolic pathways and prior research experiences in Parasitology. Experience with Plasmodium culture is a plus but not required.

Questions ?

Pr. Rachel Cerdan (Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser.)

Date de début:

Sept/Oct 2021

Plus d'informations et candidature: 

pdfpost_doc_advert_rachel_ANR_oct2021.pdf